Sökning: "Degenerative disease"

Visar resultat 21 - 25 av 83 avhandlingar innehållade orden Degenerative disease.

  1. 21. Neuroradiological aspects of multiple sclerosis : from early signs to late disease stages

    Författare :Tobias Granberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system and a leading cause of neurological disability in young adults. Magnetic resonance imaging (MRI) has improved the diagnostic process in MS, but has also led to incidental MS-like findings. LÄS MER

  3. 22. The role of nuclear envelope proteins in chromatin organization, differentiation and disease

    Författare :Cecilia Bergqvist; Einar Hallberg; Philippe Collas; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nuclear envelope proteins; chromatin organization; epigenetics; differentiation; quantitative image analysis; Samp1; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : In eukaryotes the genetic material is separated from the cytoplasm by the nuclear envelope (NE), consisting of the outer and inner nuclear membrane, the nuclear lamina and the nuclear pores. The genetic material is highly structured with transcriptionally inactive heterochromatin enriched at the nuclear periphery and transcriptionally active euchromatin in the nuclear interior. LÄS MER

  4. 23. Peripheral neuropathy and altered cobalamin metabolism in Parkinson's disease and other movement disorders

    Författare :Mattias Andréasson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Peripheral neuropathy is a disorder of the peripheral nervous system (PNS) that may carry different underlying aetiologies. Studies have suggested PNS involvement may be prevalent in neurological diseases that traditionally have been regarded primarily as disorders of the central nervous system (CNS), including the neurodegenerative disorder Parkinson’s disease (PD). LÄS MER

  5. 24. Clinical and surgical aspects of treatment of degenerative and traumatic rotator cuff tears

    Författare :Soheila Zhaeentan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pain caused by rotator cuff pathology or tear is a major source of discomfort and dysfunction in the shoulder joint. The prevalence of rotator cuff tear increases with age and also as the workforce becomes older. LÄS MER

  7. 25. Neurorestorative strategies involving neurogenesis, neuronal precursors and stem cells in animal models of Parkinson's disease

    Författare :Ming Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Parkinson s disease; substantia nigra pars compacta; adult neurogenesis; stereology; apoptosis; dopamine; tyrosine hydroxylase; nestin; 5-bromodeoxyuridine; [3H]-thymidine; MPTP; 6-OHDA; platelet-derived growth factor-BB;

    Sammanfattning : The general aims of the thesis is to provide evidence for neurogenesis in the adult substantia nigra pars compacta (SNpc), where the dopamine-producing neurons lost in Parkinson's disease (PD) reside; to optimize methods used for detecting newborn nerve cells in adult brain regions with a low rate of neurogenesis; to explore the mechanism of nerve cell death in animal models of parkinsonism and early degenerative and restorative changes in nigral cell populations; and to develop a therapeutic approach that could translate into a future restorative disease-modifying strategy in PD. Paper I. LÄS MER