Sökning: "Data-independent acquisition"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Data-independent acquisition.
1. DNA adductomics: Method development and integration in biological effect monitoring
Sammanfattning : Environmental omics can provide informative biomarkers for identifying pathologies or physiological responses to environmental change. Nucleic acid adductomics, one of the newest omics techniques, is particularly well suited for assessing exposure and effects of environmental contaminants because the technique can capture modifications at the (epi)genome level. LÄS MER
2. Mapping the proteome with data-driven methods: A cycle of measurement, modeling, hypothesis generation, and engineering
Sammanfattning : The living cell exhibits emergence of complex behavior and its modeling requires a systemic, integrative approach if we are to thoroughly understand and harness it. The work in this thesis has had the more narrow aim of quantitatively characterizing and mapping the proteome using data-driven methods, as proteins perform most functional and structural roles within the cell. LÄS MER
3. Intelligent data acquisition for drug design through combinatorial library design
Sammanfattning : A problem that occurs in machine learning methods for drug discovery is a need for standardized data. Methods and interest exist for producing new data but due to material and budget constraints it is desirable that each iteration of producing data is as efficient as possible. LÄS MER
4. Machine Learning methods in shotgun proteomics
Sammanfattning : As high-throughput biology experiments generate increasing amounts of data, the field is naturally turning to data-driven methods for the analysis and extraction of novel insights. These insights into biological systems are crucial for understanding disease progression, drug targets, treatment development, and diagnostics methods, ultimately leading to improving human health and well-being, as well as, deeper insight into cellular biology. LÄS MER
5. Proteome-wide analysis of severe bacterial infections. The battle between host and pathogen
Sammanfattning : The pathogenesis of severe infectious diseases is a complex interplay between the host and the pathogen. The development and progression of a disease encompasses a multitude of processes, which balance between host-damage and host-protection. LÄS MER