Sökning: "computational proteomics"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden computational proteomics.

  1. 1. Machine Learning methods in shotgun proteomics

    Författare :Patrick Truong; Lukas Käll; Peter Nilsson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mass spectrometry protein summarization Bayesian hierarchical modelling label-free quantification data-independent acquisition mass spectrometry; benchmark mathematical methods; transformers; computational proteomics; proteomics; bioinformatics; bert; ms2 intensity; probabilistic modelling; Biotechnology; Bioteknologi;

    Sammanfattning : As high-throughput biology experiments generate increasing amounts of data, the field is naturally turning to data-driven methods for the analysis and extraction of novel insights. These insights into biological systems are crucial for understanding disease progression, drug targets, treatment development, and diagnostics methods, ultimately leading to improving human health and well-being, as well as, deeper insight into cellular biology. LÄS MER

  3. 2. A multivariate approach to computational molecular biology

    Författare :Fredrik Pettersson; Michael Sjöström; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PLS; PCA; biomarker; Drosophila; SNP; linkage; disequilibrium; bioinformatics; computational; molecular; biology; genomics; microarray; SELDI; proteomics; Bioinformatics; Bioinformatik;

    Sammanfattning : This thesis describes the application of multivariate methods in analyses of genomic DNA sequences, gene expression and protein synthesis, which represent each of the steps in the central dogma of biology. The recent finalisation of large sequencing projects has given us a definable core of genetic data and large-scale methods for the dynamic quantification of gene expression and protein synthesis. LÄS MER

  4. 3. Computational methods for analysis of fragmented sequence data

    Författare :Fredrik Boulund; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; metagenomics; proteomics; sequencing; distributed computing; bioinformatics;

    Sammanfattning : Recent developments in genomic and proteomic sequencing technologies have revolutionized research in life sciences, providing new opportunities for the study of biological systems. However, modern sequence data sets are large, diverse, and heavily fragmented, which presents new challenges for their analysis and interpretation. LÄS MER

  5. 4. The accuracy of statistical confidence estimates in shotgun proteomics

    Författare :Viktor Granholm; Lukas Käll; Alexey Nesvizhskii; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Proteomics; Peptides; Statistics; Mass spectrometry; Tandem mass spectrometry; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

    Sammanfattning : High-throughput techniques are currently some of the most promising methods to study molecular biology, with the potential to improve medicine and enable new biological applications. In proteomics, the large scale study of proteins, the leading method is mass spectrometry. LÄS MER

  7. 5. Quantitative analysis of mass spectrometry proteomics data : Software for improved life science

    Författare :Johan Teleman; Institutionen för immunteknologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; computational proteomics; bioinformatics; life science; data complexity; algorithms; mass spectrometry;

    Sammanfattning : The rapid advances in life science, including the sequencing of the human genome and numerous other techiques, has given an extraordinary ability to aquire data on biological systems and human disease. Even so, drug development costs are higher than ever, while the rate of new approved treatments is historically low. LÄS MER