Sökning: "APOEε4"
Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet APOEε4.
1. Omega-3 fatty acid treatment in mild to moderate Alzheimer's disease : results from the OmegAD study
Sammanfattning : Alzheimer's disease (AD) is a major public health concern in all countries with an increasing prevalence. It is expected to quadruple by the year 2047. LÄS MER
2. Links between plasma apoE and glucose metabolism, brain insulin signaling, and synaptic integrity : Relevance to Alzheimer’s disease pathophysiology
Sammanfattning : Human apolipoprotein E (apoE) exists as three main isoforms called apoE2, apoE3, and apoE4, of which the E4 isoform is associated with increased Alzheimer’s disease (AD) risk. Brain glucose hypometabolism, linked to synaptic dysfunction, occurs years before symptom onset in AD, especially in APOEε4-carriers. LÄS MER
3. Hormones, biomarkers, genetics and prognostication of patients suffering severe traumatic brain injury
Sammanfattning : Severe traumatic brain injury (sTBI) is a significant cause of mortality and mobidity worldwide. In Umeå University Hospital, at the department of Neurosurgery, patients with sTBI are treated by the Lund concept, which can be characterized as an intracranial pressure (ICP) targeted therapy. LÄS MER
4. Diagnosis and monitoring of sport-related concussion
Sammanfattning : Background: Concussions are one of the most common sport-related injuries and it is known that they cause axonal and glial damage, and that there are risks for long-term effects. The aims of this thesis were to find possible methods, which may help clinicians to diagnose and monitor mild traumatic brain injury (TBI), analyse the APOEε4 allele genotype that has been associated with poor outcome after TBI and evaluate the relationship between neuropsychological assessment and brain injury biomarkers in the cerebrospinal fluid (CSF). LÄS MER
5. A stargazer's guide to neurodegeneration : Astrocytes' role in the propagation of pathological proteins
Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by brain accumulation of pathogenic protein aggregates. In the AD brain, amyloid-β (Aβ) and tau form plaques respective tangles, while in the PD brain α-synuclein (α-syn) form Lewy bodies and Lewy neurites. LÄS MER