Sökning: "DAD"

Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet DAD.

  1. 1. Multivariate spectroscopic methods for the analysis of solutions

    Författare :Kent Wiberg; Sven Jacobsson; Lars Nørgaard; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; UV-Vis spectroscopy; Multivariate calibration; Lidocaine; Identity; Content; PLS; SIMCA; Non-column; Diode array UV spectroscopy; DAD; Control sample; High Capacity Analysis HCA ; Fluorescence spectroscopy; Albumin; Immunoglobulin G; HPLC-DAD; Prilocaine; Peak purity determination; PCA; PARAFAC; Partial separation; Curve resolution; Analytical chemistry; Analytisk kemi;

    Sammanfattning : In this thesis some multivariate spectroscopic methods for the analysis of solutions are proposed. Spectroscopy and multivariate data analysis form a powerful combination for obtaining both quantitative and qualitative information and it is shown how spectroscopic techniques in combination with chemometric data evaluation can be used to obtain rapid, simple and efficient analytical methods. LÄS MER

  3. 2. Development and Validation of HPLC Methods for Analytical and Preparative Purposes

    Författare :Johan Lindholm; Torgny Fornstedt; Karin Caldwell; Karl-Gustaf Wahlund; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; High performance liquid chromatography HPLC ; Analytical biotechnology; Sample preparation; Diode-array-detection DAD ; Mass spectrometry MS ; Validation; Preparative chromatography; Competitive isotherm parameters; Perturbation peak PP method; Kemi; Chemistry; Kemi;

    Sammanfattning : This thesis concerns the development and validation of high performance liquid chromatography (HPLC) methods aimed for two industrially important areas: (i) analysis of biotechnological synthesis and (ii) determination of adsorption isotherm parameters. There is today a lack of detailed recommendations for analytical procedures in the field of biotechnological production of drugs. LÄS MER

  4. 3. Essays on Distance Based (Non-Euclidean) Tests for Spatial Clustering in Inhomogeneous Populations : Adjusting for the Inhomogeneity through the Distance Used

    Författare :Ulla Romild; Johan Lyhagen; Anders Ågren; Jack Cuzick; Uppsala universitet; []
    Nyckelord :Statistics; Clustering; Spatial Point Pattern; Inhomogeneous Density; Statistik;

    Sammanfattning : This thesis consits of four papers dealing with distance based (non-Euclidean) tests for spatial clustering in inhomogeneous populations. The density adjusted distance (DAD), which considers the underlying density, is defined in the first paper. LÄS MER

  5. 4. Omega-3 fatty acid treatment in mild to moderate Alzheimer's disease : results from the OmegAD study

    Författare :Yvonne Freund-Levi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer s disease; progressive neurodegenerative disease; omega-3 fatty acid n-3 FA docosahexaenoic acid; DHA; eicosapentatenoic acid; EPA; linoleic acid; LA; acetylcholinesterase inhibitors; AChEI; Minimental State Examination; MMSE; ADAS-cog; Clinical Dementia Rating scale; CDR; Neuropsychiatric Inventory; NPI; Montgomery Åsberg Depression Rating scale; MADRS; Disability Assessment for Dementia; DAD; Care givers burden CGB; APOEε4; hs-CRP; IL-6; TNF-α and sIL-RII; Aβ42; T-tau and P-tau; weight; Body Mass Index; BMI.;

    Sammanfattning : Alzheimer's disease (AD) is a major public health concern in all countries with an increasing prevalence. It is expected to quadruple by the year 2047. LÄS MER

  7. 5. Synthesis of donor–acceptor–donor thiophene based ligands that can be utilized for optical assignment of pathological targets

    Författare :Linda Lantz; Peter Nilsson; Peter Konradsson; Jerker Mårtensson; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Thiophene based ligands represent a class of molecular reporters proven superior in discerning pathological targets involved in neurodegenerative diseases, as well as bacterial infection. By fluorometric detection that depends on the milieu surrounding the ligand these biological processes can be studied with fluorescence spectroscopy and hyper-spectral confocal microscopy. LÄS MER