Sökning: "Aβ42"

Visar resultat 1 - 5 av 50 avhandlingar innehållade ordet Aβ42.

  1. 1. Co-assembly of proteins and lipids : From lipodiscs to amyloid aggregates

    Författare :Rebecca Frankel Willén; NanoLund: Centre for Nanoscience; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; amyloid; Aβ42; apolipoprotein A-1; aggregation; high-density lipoprotein; DNAJB6; Alzheimer s disease; protein-lipid interactions;

    Sammanfattning : Assemblies of different molecules is a prevalent phenomenon in nature, and crucial in biological life. Most of the biological assemblies are co-assembledcomposites, made up from several different components, either of thesame biomolecular type or a combination of different ones. LÄS MER

  3. 2. Amyloid β peptide: from monomer solubility to fibril structure

    Författare :Veronica Lattanzi; NanoLund: Centre for Nanoscience; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer´s disease; Aβ solubility; small angle scattering; number of filaments; Aβ40; Aβ42 and Aβ42 S26Q ; fibril structure;

    Sammanfattning : Alzheimer´s disease (AD) is the most common human neuro-degenerative disease characterized by the formation of cerebral plaques. Several are the amyloid-beta (Aβ) variants found in the brain of healthy individuals. LÄS MER

  4. 3. Alzheimer disease : a super-resolved picture of the amyloid β-peptide producing machinery

    Författare :Yang Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer disease (AD) is the most common neurodegenerative disease, influencing 40 million patients in the world. Pathologically, AD is hallmarked by intracellular tau tangles and extracellular Amyloid-β peptide (Aβ) plaques. Aβ is generated from the amyloid precursor protein (APP) and its C-terminal fragment (APP-CTF). LÄS MER

  5. 4. Alzheimer disease : subcellular Aβ mechanisms and treatment strategies

    Författare :Yang Gao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The amyloid β-peptide (Aβ) is the key molecule in the pathogenesis of Alzheimer disease (AD), but the mechanisms of its toxicity are still largely unknown. This thesis includes studies aimed at studying Aβ induced mechanisms in neurons at the subcellular level and explore effective AD treatment strategies. LÄS MER

  7. 5. Prediction of Alzheimer’s disease in subjects with Mild Cognitive Impairment using biomarkers

    Författare :Peder Buchhave; Klinisk minnesforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Mild Cognitive Impairment; Biomarkers; Prediction; Cerebrospinal fluid; Amyloid.;

    Sammanfattning : Background: Alzheimer’s disease (AD) is the most common cause of dementia. In order to have effect of future disease-modifying therapies for AD, the disease must be identified early, before the patients have developed dementia. Many patients with Mild Cognitive Impairment (MCI) have prodromal AD, but other causes for the syndrome are common. LÄS MER