Sökning: "AA"

Visar resultat 26 - 30 av 198 avhandlingar innehållade ordet AA.

  1. 26. Analysis of DNA adducts of some low molecular weight aldehydes : methods development and application in human biomonitoring

    Författare :Jia-Long Fang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malondialdehyde (MA), acetaldehyde (Aa) and methylglyoxal (MG) are ubiquitously present in the environment and endogenously formed in animals and humans. They have been shown to be genotoxic and to readily react with DNA to form DNA adducts under physiological conditions. LÄS MER

  3. 27. In Vitro Kinetics of Ribosomal Incorporation of Unnatural Amino Acids

    Författare :Jinfan Wang; Anthony Forster; Jason Chin; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ribosome; protein synthesis; unnatural amino acids; kinetics; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : Ribosomal incorporation of unnatural amino acids (AAs) into peptides or proteins has found broad applications in studying translation mechanism, discovering potential therapeutics, and probing protein structure and function. However, such applications are generally limited by the low incorporation efficiencies of the unnatural AAs. LÄS MER

  4. 28. Functional analysis of the -1087 single nucleotide polymorphism in the IL-10 promoter region

    Författare :Lena Larsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL-10; B cells; Sp1; transcription factors; gene expression;

    Sammanfattning : Interleukin (IL) 10 is recognized as a pro-inflammatory cytokine that promotes B cell proliferation. The objectives of the present series of studies were to analyze (i) differences in transcription factor binding to the -1087 IL-10 gene polymorphism in B cells, (ii) the influence of the A to G nucleotide transition on IL-10 and Sp1 gene expression in B cells, (iii) differences in Sp1 expression in periodontitis lesions from GG and AA genotype subjects and (iv) epigenetic modifications around the -1087 site and their influence on IL-10 gene expression. LÄS MER

  5. 29. Design and Synthesis of Potential Aminoacyl-tRNA Synthetase Inhibitors

    Författare :Itedale Namro Redwan; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aminoacyl tRNA synthetases; Aminoacyl-AMP; Bioisosteres; Amino Acids; Solution-Phase; Protective Groups; Solid-Phase Chemistry; Molecular Modelling; Biological Evaluation;

    Sammanfattning : Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes present in all living organisms, their catalytic activity is involved in the translation of the genetic code into functional proteins and they are potential targets for anti-infective agents. The first step in the biosynthetic pathway catalysed by aaRSs consists of activation of the corresponding amino acid by the reaction with ATP to form an aminoacyl-adenylate (aa-AMP), the key intermediate in the biosynthesis of proteins. LÄS MER

  7. 30. Regulation of aortic wall mechanics and stress : An experimental study in man

    Författare :Håkan Åstrand; Toste Länne; Matts Karlsson; Martin Björck; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aorta; wall stress; remodeling; IMT; gender; diabetes mellitus; aging; collagen; elastin; Vascular surgery; Kärlkirurgi;

    Sammanfattning : The abdominal aorta (AA) in man is a vulnerable artery prone to atherosclerosis as well as aneurysmatic dilation. The underlying aortic composition, mechanical properties as well as the mechanisms responsible for age-related changes and vascular disease are however largely unknown. LÄS MER