Sökning: "Aminoacyl tRNA synthetases"

Hittade 3 avhandlingar innehållade orden Aminoacyl tRNA synthetases.

  1. 1. Design and Synthesis of Potential Aminoacyl-tRNA Synthetase Inhibitors

    Författare :Itedale Namro Redwan; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aminoacyl tRNA synthetases; Aminoacyl-AMP; Bioisosteres; Amino Acids; Solution-Phase; Protective Groups; Solid-Phase Chemistry; Molecular Modelling; Biological Evaluation;

    Sammanfattning : Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes present in all living organisms, their catalytic activity is involved in the translation of the genetic code into functional proteins and they are potential targets for anti-infective agents. The first step in the biosynthetic pathway catalysed by aaRSs consists of activation of the corresponding amino acid by the reaction with ATP to form an aminoacyl-adenylate (aa-AMP), the key intermediate in the biosynthesis of proteins. LÄS MER

  3. 2. Aminoacyl tRNA synthetases and their connection to autoimmune rheumatic disease

    Författare :Charlotta Preger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Idiopathic inflammatory myopathies (IIM, collectively called myositis) are rare autoimmune rheumatic diseases characterized by chronic inflammation and associated with high mortality and morbidity (1, 2). The disease nomenclature tells us that IIM has traditionally been described as a group of diseases mainly affecting the skeletal muscle, with muscle weakness and weakened muscle endurance as the dominating clinical symptoms (3). LÄS MER

  4. 3. Constraints on up-regulation of drug efflux in the evolution of ciprofloxacin resistance

    Författare :Lisa Praski Alzrigat; Diarmaid Hughes; Fernando Baquero; Uppsala universitet; []
    Nyckelord :ciprofloxacin; antibiotic resistance; drug efflux; bacterial fitness; marR; acrR; marA; experimental evolution; Mikrobiologi; Microbiology;

    Sammanfattning : The crucial role of antibiotics in modern medicine, in curing infections and enabling advanced medical procedures, is being threatened by the increasing frequency of resistant bacteria. Better understanding of the forces selecting resistance mutations could help develop strategies to optimize the use of antibiotics and slow the spread of resistance. LÄS MER