Sökning: "Itedale Namro Redwan"

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  1. 1. Design and Synthesis of Potential Aminoacyl-tRNA Synthetase Inhibitors

    Författare :Itedale Namro Redwan; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :Aminoacyl tRNA synthetases; Aminoacyl-AMP; Bioisosteres; Amino Acids; Solution-Phase; Protective Groups; Solid-Phase Chemistry; Molecular Modelling; Biological Evaluation;

    Sammanfattning : Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes present in all living organisms, their catalytic activity is involved in the translation of the genetic code into functional proteins and they are potential targets for anti-infective agents. The first step in the biosynthetic pathway catalysed by aaRSs consists of activation of the corresponding amino acid by the reaction with ATP to form an aminoacyl-adenylate (aa-AMP), the key intermediate in the biosynthesis of proteins. LÄS MER