Sökning: "5HT"

Visar resultat 11 - 15 av 15 avhandlingar innehållade ordet 5HT.

1. 11. The use of adipose derived stem cells in spinal cord and peripheral nerve repair

   Författare :Mallappa K Kolar; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spinal cord injury; peripheral nerve injury; adipose derived stem cells; regeneration; neurotrophic factor; angiogenic factor;

   Sammanfattning : Clinically, injuries affecting the spinal cord or peripheral nerves can leave those affected with severe disability and, at present, there are limited options for treatment. Peripheral nerve injury with a significant gap between the proximal and distal stumps is currently treated with autologous nerve grafting but this is limited by availability of donor nerve and has associated morbidities. LÄS MER

3. 12. Modulatory effects and interactions of substance P, dopamine and 5-HT in a neuronal network

   Författare :Erik Svensson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Lamprey; spinal cord; neuromodulation; substance P; 5-HT; dopamine;

   Sammanfattning : The spinal neuronal network that generates the locomotor rhythm in lamprey contains excitatory and inhibitory interneurons, reticulospinal inputs from the brainstem, and motor neurons. In this thesis, I have studied how the spinal locomotor network cart be modulated by a tachykinin, dopamine and 5- HT that are co-localized in midline neurons situated below the central canal. LÄS MER

4. 13. Neuroactive steroids and rat CNS

   Författare :Vita Birzniece; Bo Söderpalm; Umeå universitet; []
   Nyckelord :Estradiol; progesterone; HRT; allopregnanolone; UC1011; serotonin receptor; GABAA receptor; mRNA; Morris water maze; silent second; tolerance; Clinical Neurophysiology; klinisk neurofysiologi;

   Sammanfattning : Several studies suggest profound effects on mood and cognition by neuroactive steroids. Estrogen alone or in combination with antidepressant drugs affecting the serotonin system has been used to treat mood disorders. On the other hand, progesterone is related to negative effects on mood and memory. LÄS MER

5. 14. Transplantation of mesenchymal stem cells and injections of microRNA as therapeutics for nervous system repair

   Författare :Mallappa K. Kolar; Lev N. Novikov; Paul J. Kingham; Mikael Wiberg; Elisabet Åkesson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spinal cord injury; peripheral nerve injury; mesenchymal stem cells; regeneration; neurotrophic factor; angiogenic factor;

   Sammanfattning : Traumatic injuries to the spinal cord (SCI) and peripheral nerve (PNI) affect several thousand people worldwide every year. At present, there is no effective treatment for SCI and despite continuous improvements in microsurgical reconstructive techniques for PNI, many patients are still left with permanent, devastating neurological dysfunction. LÄS MER

7. 15. PET studies of the serotonin transporter in the human brain

   Författare :Johan Lundberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :positron emission tomography; MADAM; WAY 100635; 5-HTT; 5-HT1A receptors; receptor occupancy; major depressive disorder; citalopram; escitalopram;

   Sammanfattning : The serotonin (5-HT) system attracts considerable attention in research on the pathophysiology and drug treatment of neuropsychiatric disorders. The brain imaging technique Positron Emission Tomography (PET) allows for examination of neurotransmission systems in the human brain in vivo. LÄS MER