Sökning: "5HT"
Visar resultat 6 - 10 av 15 avhandlingar innehållade ordet 5HT.
6. Imaging and Quantification of Brain Serotonergic Activity using PET
Sammanfattning : This thesis investigates the potential of using positron emission tomography (PET) to study the biosynthesis and release of serotonin (5HT) at the brain serotonergic neuron. As PET requires probe compounds with specific attributes to enable imaging and quantification of biological processes, emphasis was placed on the evaluation of these attributes. LÄS MER
7. Studies on 5-hydroxytryptophol and the metabolic interaction between serotonin and ethanol
Sammanfattning : The biogenic amine serotonin (5-hydroxytryptamine, 5HT) is most abundant within the gastrointestinal tract (GIT), in blood platelets, and in the central nervous system. The 5HT system is involved in many physiological and behavioural processes in the body. LÄS MER
8. Amine oxidases in dental pulp : a study with special regard to a semicarbazide-sensitive amine oxidase with catalytic potency towards serotonin
Sammanfattning : The amine oxidizing capacity of piglet dental pulp tissue has been investigated. At least six separate enzyme activities could be distinguished:- a soluble semicarbazide-sensitive (SSAO) activity towards benzylamine, most likely to be derived from the content of blood plasma within the pulp tissue;- a soluble pulp tissue SSAO activity with most properties in common with the plasma enzyme, however with great efficiency not only regarding benzylamine but also tryptamine;- a tissue bound SSAO activity with activity towards benzylamine, tryptamine, tyramine and ß-phenylethylamine;- a tissue bound semicarbazide-sensitive activity towards serotonin (SSA0-5HT) (a combination of properties never reported before);- a mitochondrially bound and clorgyline-sensitive monoamine oxidase-A (MAO-A) activity with activity towards serotonin;- a mitochondrially bound and deprenyl-sensitive MAO-B activity with activity towards e. LÄS MER
9. Provoked vestibulodynia : studies on pain genetics and pain co-morbidity
Sammanfattning : Objective: The purpose of this thesis was to investigate a possible genetic predisposition for developing provoked vestibulodynia (PVD), focusing on previously defined single nucleotide polymorphisms (SNPs) in three genes with a known influence on endogenous pain modulation: GCH1, OPRM1 and 5HT-2A. We also investigated the effects of any potential interactions between these SNPs and the use of hormonal contraceptives, serum levels of β-endorphin and symptoms of anxiety and depression, on the risk of developing PVD and general pain sensitivity. LÄS MER
10. On the molecular structure of some psychoactive drugs : studies of the antidepressant alaproclate and two potentially neuroleptic rigid spiro amines
Sammanfattning : The solid state conformations and absolute configurations of the antidepressant alaproclate and two potentially neuroleptic rigid spiro amines have been determined by X-ray crystallographic techniques.Alaproclate is a selective inhibitor of neuronal 5-hydroxytryptamine (5-HT) reuptake. LÄS MER