Sökning: "xylosides"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet xylosides.

1. 1. Tools for understanding the glycosaminoglycan biosynthesis

   Författare :Daniel Willén; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Xylosides; Glycosaminoglycans; Proteoglycans; β4GalT7; Carbohydrate synthesis; GAG priming; GAG inhibition;

   Sammanfattning : For cells to function correctly within an organism, they need different systems to communicate with each other. One crucial part of cell signaling is the proteoglycans (PGs) and glycosaminoglycans (GAGs), which are macromolecules that bind different signaling molecules and proteins necessary for processes such as growth and proliferation. LÄS MER

3. 2. Naphthoxylosides Investigations into glycosaminoglycan biosynthesis

   Författare :Mårten Jacobsson; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; proteoglycan; Organic chemistry; nucleophilic aromatic substitution; thioether; glycosaminoglycan; xylosides; naphthoxylosides;

   Sammanfattning : Glycosaminoglycans (GAGs) are members of a family of polysaccharide structures consisting mostly of repeating disaccharide units. Most GAGs are attached to specific serine residues in proteins to form proteoglycans (PGs). LÄS MER

4. 3. Exploration of the active site of β4GalT7 – Synthesis of substrates and inhibitors

   Författare :Karin Thorsheim; Centrum för analys och syntes; []
   Nyckelord :Xylosides; β4GalT7; β-1; 4-galactosyltransferase 7; glycosaminoglycan; synthesis;

   Sammanfattning : β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of proteoglycans (PGs) and glycosaminoglycan (GAG) chains, which are important macromolecules involved in many biological processes such as cell growth and cell signaling as well as in cancer pathobiology and viral and bacterial infections. Despite its pivotal role, much is still unknown regarding the specific structure of GAGs and how the structure affects its functions. LÄS MER

5. 4. Synthetic studies on naphthoxylosides - labeled compounds and mechanistic studies on acetals

   Författare :Richard Johnsson; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fluorescent xylosides; Carbohydrates; Naphthoxylosides; Cancer; Mechanistic studies; Radioactive xylosides; Acetals;

   Sammanfattning : Labeled analogs to an antiproliferative naphthoxyloside have been synthesized and evaluated. Our investigations have shown that the fluorescently labeled analogs are poor structural analogs, and the physical and biological properties are altered to a large extent. LÄS MER

7. 5. Structural and Functional Analyses of Xyloside-primed Glycosaminoglycans

   Författare :Andrea Persson; Glykobiologigruppen; []
   Nyckelord :Glycosaminoglycan; Xyloside; Chondroitin sulfate; Dermatan sulfate; Heparan sulfate; Proteoglycan; Cancer;

   Sammanfattning : Glycosaminoglycans (GAGs) are polysaccharides produced by essentially all mammalian cells. Due to their enormous structural diversity, they are involved in many biological processes both in health and disease, including all stages of tumor progression. LÄS MER