Sökning: "4-galactosyltransferase 7"

Hittade 2 avhandlingar innehållade orden 4-galactosyltransferase 7.

  1. 1. Exploration of the active site of β4GalT7 – Synthesis of substrates and inhibitors

    Författare :Karin Thorsheim; Centrum för analys och syntes; []
    Nyckelord :Xylosides; β4GalT7; β-1; 4-galactosyltransferase 7; glycosaminoglycan; synthesis;

    Sammanfattning : β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of proteoglycans (PGs) and glycosaminoglycan (GAG) chains, which are important macromolecules involved in many biological processes such as cell growth and cell signaling as well as in cancer pathobiology and viral and bacterial infections. Despite its pivotal role, much is still unknown regarding the specific structure of GAGs and how the structure affects its functions. LÄS MER

  3. 2. Naphthoxylosides – Probing the β4GalT7 active site

    Författare :Anna Siegbahn; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Proteoglycans (PGs) is a class of highly anionic macromolecules that consist of one or more linear polysaccharide chains (glycosaminoglycans, GAGs) covalently attached to a core protein. The biological functions of PGs are mainly due to the interactions of GAG chains with various protein ligands and regulatory factors, such as cytokines and growth factors. LÄS MER