Sökning: "GAG priming"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden GAG priming.

  1. 1. Tools for understanding the glycosaminoglycan biosynthesis

    Författare :Daniel Willén; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Xylosides; Glycosaminoglycans; Proteoglycans; β4GalT7; Carbohydrate synthesis; GAG priming; GAG inhibition;

    Sammanfattning : For cells to function correctly within an organism, they need different systems to communicate with each other. One crucial part of cell signaling is the proteoglycans (PGs) and glycosaminoglycans (GAGs), which are macromolecules that bind different signaling molecules and proteins necessary for processes such as growth and proliferation. LÄS MER

  3. 2. Involvement of Heparan Sulphate Biosynthesis and Turnover in Cell Proliferation. A Novel Role for Nitric Oxide in Recycling of Heparan Sulphate Proteoglycans

    Författare :Katrin Mani; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nitrite.; nitric oxide; growth-inhibition; xyloside; glypican; heparan sulphate; Proteoglycan; glycosaminoglycan; Clinical biology; Klinisk biologi;

    Sammanfattning : The present investigation focuses on the role of HS metabolism in cell proliferation. The effect of the HS priming ß-D-xyloside, 2-(6-hydroxynaphthyl)-O-ß-D-xylopyranoside (Xyl-2-Nap-6-OH) on the proliferation of normal and transformed cells was studied. LÄS MER

  4. 3. Immune responses induced by immunization with HIV-1 DNA followed by HIV-modified vaccinia virus Ankara with or without recombinant GP140 in healthy Tanzanian individuals

    Författare :Agricola Joachim; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A vaccine against HIV is widely considered the most effective and sustainable way of preventing new infections. We previously conducted a phase I/II clinical trial using multi-clade, multigene HIV-DNA priming and boosting with the recombinant modified vaccinia Ankara (HIV-MVA) virus among healthy Tanzanian volunteers (HIVIS03 trial). LÄS MER

  5. 4. Roles in innate immune receptors : host – pathogen interactions and strengthening vaccines

    Författare :Sanna Nyström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During the past decades our knowledge of innate immunology has increased drastically. This has improved our understanding about how innate immune cells can distinguish self from non-self, commensal bacteria from pathogens, and how it affects later adaptive immune responses. LÄS MER

  7. 5. Immunomodulatory Effects of Human ImmunodeficiencyVirus (HIV-1) on Dendritic Cell and T cell Responses : Studies of HIV-1 effects on Dendritic cell functionality reflected in primed T cells

    Författare :Karlhans Fru Che; Marie Larsson; Jorma Hinkula; Karl-Eric Magnusson; Douglas Nixon; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The human immunodeficiency virus (HIV)-1 is the causative agent of acquired immune deficiency syndrome (AIDS) worldwide. Till date there are no vaccines or cure for this infection as the virus has adapted myriad ways to remain persistent in the host where it causes severe damage to the immune system. LÄS MER