Sökning: "Glycosaminoglycans"

Visar resultat 1 - 5 av 76 avhandlingar innehållade ordet Glycosaminoglycans.

  1. 1. Interactions between herpes simplex virus type 1 glycoprotein C and cell surface glycosaminoglycans

    Författare :Kristina Mårdberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Herpes simplex virus-1; glycoprotein C; virus receptor; glycosaminoglycans; heparan sulfate; chondroitin sulfate;

    Sammanfattning : The cell surface glycosaminoglycan (GAG) heparan sulfate (HS) serves as an initial receptor for herpes simplex virus type 1 (HSV-1) and virus attachment to the HS molecule is mediated by the envelope glycoprotein C (gC). In the first part of this thesis, we aimed to define the HS-binding domain of viral gC. LÄS MER

  3. 2. Interaction of herpes simplex virus with cell surface glycosaminoglycans as a target for antiviral intervention

    Författare :Kicki Bergefall; Göteborgs universitet; []
    Nyckelord :HSV; glycoproteins; glycosaminoglycans; virus receptor; antiviral drugs;

    Sammanfattning : Herpes simplex virus (HSV) infections in humans are predominantly manifested as oral cold sores or genital ulcers. As HSV infects cells by interaction with cell surface heparan sulfate (HS) and/or chondroitin sulfate (CS), the aim of the research work presented in this thesis was to explore the possibility of antiviral intervention with compounds that mimic HS or CS. LÄS MER

  4. 3. Unraveling the molecular mechanisms of herpes simplex virus attachment and release using cell membrane mimics

    Författare :Nadia Peerboom; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; total internal reflection fluorescence microscopy; glycosaminoglycans; atomic force microscopy; binding kinetics; single particle tracking; herpes simplex virus;

    Sammanfattning : The herpes simplex virus is a widespread human pathogen, most commonly known for causing cold sores. Its infection cycle is initiated with the formation of multiple bonds between viral glycoproteins and cellular glycosaminoglycans, which are long polysaccharide chains found close to the cell surface. LÄS MER

  5. 4. Tools for understanding the glycosaminoglycan biosynthesis

    Författare :Daniel Willén; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Xylosides; Glycosaminoglycans; Proteoglycans; β4GalT7; Carbohydrate synthesis; GAG priming; GAG inhibition;

    Sammanfattning : For cells to function correctly within an organism, they need different systems to communicate with each other. One crucial part of cell signaling is the proteoglycans (PGs) and glycosaminoglycans (GAGs), which are macromolecules that bind different signaling molecules and proteins necessary for processes such as growth and proliferation. LÄS MER

  7. 5. Designing biosensor platforms to study glycosaminoglycan interactions

    Författare :Noomi Altgärde; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; interaction studies; molecular immobilization; QCM-D; glycosaminoglycans; extracellular matrix;

    Sammanfattning : The importance of glycosaminoglycans (GAGs) has been highlighted in many areas of research during recent years. Not only are they important in providing structure and support to our tissues but they also function as interaction partners in the extracellular matrix and at the cell membrane. LÄS MER