Sökning: "Xyloside"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet Xyloside.

  1. 1. Structural and Functional Analyses of Xyloside-primed Glycosaminoglycans

    Författare :Andrea Persson; Glykobiologigruppen; []
    Nyckelord :Glycosaminoglycan; Xyloside; Chondroitin sulfate; Dermatan sulfate; Heparan sulfate; Proteoglycan; Cancer;

    Sammanfattning : Glycosaminoglycans (GAGs) are polysaccharides produced by essentially all mammalian cells. Due to their enormous structural diversity, they are involved in many biological processes both in health and disease, including all stages of tumor progression. LÄS MER

  3. 2. Tumor Selective Antiproliferative Naphthoxylosides

    Författare :Ulrika Aili; Glykobiologigruppen; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glycosaminoglycan; proteoglycan; heparan sulfate; xyloside; naphthoxyloside; histone H3 acetylation;

    Sammanfattning : Proteoglycans (PG) are highly anionic macromolecules consisting of a core protein covalently substituted with long unbranched polysaccharide chains called glycosaminoglycans (GAGs). PGs are central components in multicellular organisms, and they may occur in the extracellular matrix (ECM), at the cell surface, or in the secretory pathway. LÄS MER

  4. 3. Involvement of Heparan Sulphate Biosynthesis and Turnover in Cell Proliferation. A Novel Role for Nitric Oxide in Recycling of Heparan Sulphate Proteoglycans

    Författare :Katrin Mani; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nitrite.; nitric oxide; growth-inhibition; xyloside; glypican; heparan sulphate; Proteoglycan; glycosaminoglycan; Clinical biology; Klinisk biologi;

    Sammanfattning : The present investigation focuses on the role of HS metabolism in cell proliferation. The effect of the HS priming ß-D-xyloside, 2-(6-hydroxynaphthyl)-O-ß-D-xylopyranoside (Xyl-2-Nap-6-OH) on the proliferation of normal and transformed cells was studied. LÄS MER

  5. 4. Exploration of the active site of β4GalT7 – Synthesis of substrates and inhibitors

    Författare :Karin Thorsheim; Centrum för analys och syntes; []
    Nyckelord :Xylosides; β4GalT7; β-1; 4-galactosyltransferase 7; glycosaminoglycan; synthesis;

    Sammanfattning : β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of proteoglycans (PGs) and glycosaminoglycan (GAG) chains, which are important macromolecules involved in many biological processes such as cell growth and cell signaling as well as in cancer pathobiology and viral and bacterial infections. Despite its pivotal role, much is still unknown regarding the specific structure of GAGs and how the structure affects its functions. LÄS MER

  7. 5. Interaction between nerve fiber formation and astrocytes

    Författare :Sanazalsadat Hashemian; Ingrid Strömberg; Elisabet Åkesson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dopamine; nerve fiber outgrowth; astrocytes; ventral mesencephalon; spinal cord; CSPG; CD47;

    Sammanfattning : Parkinson’s disease, the second most common neurodegenerative disorder,is characterized by loss of nigrostriatal dopaminergic neurons. To date,there is no defined cause and cure for the disease. An ideal treatmentstrategy is to replace the lost neurons by transplanting fetal dopaminergicneurons to the brain of parkinsonian patients. LÄS MER