Sökning: "whole genome sequence"

Visar resultat 11 - 15 av 76 avhandlingar innehållade orden whole genome sequence.

1. 11. Genetic Sequence Analysis by Microarray Technology

   Författare :Emilie Hultin; Joakim Lundeberg; Afshin Ahmadian; Marie Allen; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Genotyping; single nucleotide polymorphism SNP ; protease-mediated allele-specific extension PrASE ; microarray; tag-array; competitive hybridization; human papillomavirus HPV ; single cell; loss of alleles; differentiation; epidermis.; Bioengineering; Bioteknik;

   Sammanfattning : Developments within the field of genetic analysis have during the last decade become enormous. Advances in DNA sequencing technology have increased throughput from a thousand bases to over a billion bases in a day and decreased the cost thousandfold per base. LÄS MER

3. 12. Bioinformatic analysis of whole genome sequencing data : detection of selective sweeps and structural changes

   Författare :Khurram Maqbool; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Evolution has shaped the life forms for billion of years. Domestication is an accelerated process that can be used as a model for evolutionary changes. The aim of this thesis project has been to carry out extensive bioinformatic analyses of whole genome sequencing data to reveal SNPs, InDels and selective sweeps in the chicken, pig and dog genome. LÄS MER

4. 13. Meiotic Recombination in Human and Dog : Targets, Consequences and Implications for Genome Evolution

   Författare :Jonas Berglund; Matthew Webster; Kerstin Lindblad-Toh; Leif Andersson; Nadia Singh; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; recombination; biased gene conversion; CpG island; copy number variation; substitutions; methylation; Bioinformatics; Bioinformatik; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution; Molekylär genetik; Molecular Genetics;

   Sammanfattning : Understanding the mechanism of recombination has important implications for genome evolution and genomic variability. The work presented in this thesis studies the properties of recombination by investigating the effects it has on genome evolution in humans and dogs. LÄS MER

5. 14. Molecular epidemiology of Staphylococcus epidermidis in prosthetic joint infections

   Författare :Emeli Månsson; Bo Söderquist; Martin Sundqvist; Åsa Nilsdotter-Augustinsson; Eva Särndahl; Kåre Bergh; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Staphylococcus epidermidis; molecular epidemiology; prosthetic joint infections; whole genome sequencing; Staphylococcus pettenkoferi;

   Sammanfattning : Staphylococcus epidermidis is ubiquitous in the human microbiota, but also an important pathogen in healthcare-associated infections, such as prosthetic joint infections (PJIs). In this thesis, aspects of the molecular epidemiology of S. LÄS MER

7. 15. Analysis of Nucleotide Variations in Non-human Primates

   Författare :Ann-Charlotte Rönn; Ann-Christine Syvänen; Mats Nilsson; Phillip Morin; Uppsala universitet; []
   Nyckelord :Molecular genetics; SNP; genotyping; primate; chimpanzee; whole genome amplification; multiple displacement amplification; minisequencing; microarray; Y-chromosome; mitochondria; Genetik;

   Sammanfattning : Many of our closest relatives, the primates, are endangered and could be extinct in a near future. To increase the knowledge of non-human primate genomes, and at the same time acquire information on our own genomic evolution, studies using high-throughput technologies are applied, which raises the demand for large amounts of high quality DNA. LÄS MER