Sökning: "two-dimensional liquid chromatography"

Visar resultat 11 - 15 av 22 avhandlingar innehållade orden two-dimensional liquid chromatography.

1. 11. Proteome studies, with emphasis on the kidney glomerulus

   Författare :Sam Tryggvason; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Proteomics aims to link genes to protein expression and function. Proteomics is a very versatile and technology-dependent discipline and the development of mass spectrometry-based proteomics has advanced the understanding of the complex and dynamic nature of proteomes. LÄS MER

3. 12. Electrifying the Molecules of Life : Peptide and Protein Analysis by Capillary Electrophoresis Coupled to Electrospray Ionization Mass Spectrometry

   Författare :Magnus Wetterhall; Jonas Bergquist; Karin E. Markides; Dominic M. Desiderio; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Capillary electrophoresis CE ; Electrospray ionization ESI ; Mass spectrometry MS ; Peptides; Proteins; Cerebrospinal fluid CSF ; Graphite coating; Monomer coating; Polymer coating; Analytisk kemi; Analytical chemistry; Analytisk kemi;

   Sammanfattning : This thesis describes the current status and novel aspects of the analysis of the molecules of life, i.e. peptides and proteins, using capillary electrophoresis (CE) coupled to mass spectrometry (MS) via (sheathless) electrospray ionization (ESI). Early reports of sheathless CE-ESI-MS were plagued by limited lifetimes of the electrospray emitter. LÄS MER

4. 13. The Bronchoalveolar Lavage Proteome- Phenotypic associations to smoking and divergence towards development of COPD

   Författare :Amelie Plymoth; allergologi och palliativ medicin Lungmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Andningsorganen; Respiratory system; mass spectrometry; proteomics; 2-D gel; COPD; bronchoalveolar lavage;

   Sammanfattning : Proteomic analysis of bronchoalveolar lavage (BAL) fluid from smokers at risk of developing chronic obstructive pulmonary disease (COPD) and never smokers is described. COPD is currently the world's fourth leading cause of death and its prevalence is increasing. LÄS MER

5. 14. Development of Methods for Protein and Peptide Analysis Applied in Neuroscience Utilizing Mass Spectrometry

   Författare :Johan Pierson; Per Andrén; Ulf Bondesson; György Marko-Varga; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Mass spectrometry; Parkinson’s disease; Metabolism; Profiling Mass Spectrometry; Proteomics; Analytisk kemi; Analytical chemistry; Analytisk kemi;

   Sammanfattning : This thesis describes the utilization of the matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) and electrospray ionization (ESI) MS techniques for analysis of complex brain tissue samples. Direct molecular profiling of biological samples using MALDI MS is a powerful tool for identifying phenotypic markers. LÄS MER

7. 15. Mass spectrometry for comparative proteomics of degenerative and regenerative processes in the brain

   Författare :Carina Sihlbom; Göteborgs universitet; []
   Nyckelord :glycoproteomics; quantitative proteomics; glycoprotein; protein quantification; glycosylation; Fourier transform ion cyclotron mass spectrometry; cerebrospinal fluid; Alzheimer s disease; neurodegeneration; neuroregeneration; hippocampus; astrocytes; brain injury; 14-3-3 protein; isoform;

   Sammanfattning : Biological processes involve changes at the protein level. Proteomics aims to determine protein changes from a normal state, to measure for instance recovery or disease progression. Mass spectrometry is the most important tool for identification of proteins and determination of post-translational modifications such as glycosylation. LÄS MER