Sökning: "tumor microenvironment"

Visar resultat 31 - 35 av 195 avhandlingar innehållade orden tumor microenvironment.

  1. 31. Decoding the tumor microenvironment : a B-cell and macrophage perspective

    Författare :Vanessa F Boura; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The immune system plays a role in many different functions in our body, and disease is no exception. Cancer is one of the biggest challenges of the twenty first century and vast efforts have been made to understand this disease. LÄS MER

  3. 32. Epidemiology and prognosis in classical Hodgkin lymphoma

    Författare :Peter Hollander; Ingrid Glimelius; Rose-Marie Amini; Gunilla Enblad; Lydia Visser; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epstein-Barr virus; rheumatoid arthritis; tumor microenvironment; immunohistochemistry; immune checkpoints; regulatory T lymphocytes; PD-1; PD-L1; Oncology; Onkologi; Patologi; Pathology;

    Sammanfattning : Classical Hodgkin lymphoma (HL) is a B cell derived neoplasm with an overall good prognosis. Its etiology and pathogenesis are largely unknown. The tumor microenvironment consists of sparse malignant cells and abundant leukocytes. LÄS MER

  4. 33. Profiling of microglia in inflammation, aging, and the tumor microenvironment

    Författare :Lara Friess; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In this thesis I aim to present our ongoing efforts to elucidate activation states and how these are regulated in microglia cells. An extensive body of work is dedicated to understanding how these resident immune cells can acquire certain activation states, as their roles are crucial for a great range of functions in the central nervous system – from homeostasis to pathological occurrences. LÄS MER

  5. 34. Targeting stromal components in the tumor microenvironment for cancer therapy

    Författare :Jieyu Wu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the tumor microenvironment (TME), different cell components crosstalk with each other through various growth factors, cytokines, chemokines, and enzymes. They offered crucial survival signals for tumor cell proliferation and metastasis. LÄS MER

  7. 35. Mechanisms for immune escape in epithelial ovarian cancer

    Författare :Pernilla Israelsson; Ulrika Ottander; Lucia Mincheva-Nilsson; Eva Lundin; Ivan Nagaev; Karin Sundfeldt; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; ovarian cancer; high-grade serous cancer; EOC; HGSC; HGSOC; tumor microenvironment; immune escape; immune suppression; cytokines; exosomes; NKG2D; MICA B; ULBP1-3; DNAM-1; surgery; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : Tumors develop mechanisms to subvert the immune system, constituting immune escape. Epithelial ovarian cancer (EOC), the deadliest of all gynecological malignancies, uses a variety of mechanisms to undermine immune surveillance, aiding its establishment and metastatic spreading. LÄS MER