Sökning: "structural biology"

Visar resultat 26 - 30 av 628 avhandlingar innehållade orden structural biology.

1. 26. Structural Studies of Flexible Biomolecules and a DNA-binding Protein

   Författare :Tariq Massad; Pål Stenmark; Cheryl Arrowsmith; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Maximum entropy; motilin; DNA-binding proteins; Karplus equation; disaccaride; direct repeats; Structural biology; Strukturbiologi; Biophysics; biofysik;

   Sammanfattning : The knowledge of the three-dimensional structures of proteins and polypeptides is essential to understand their functions. The work shown in this thesis has two objectives. LÄS MER

3. 27. Combined structural methods to characterize an oligomeric small heat shock protein Hsp21

   Författare :Gudrun Rutsdottir; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Small heat shock proteins; chaperones; crosslinking mass spectrometry; Stable isotope labeling; quantification; small angle X-ray scattering; cryo-electron microscopy; combined structural methods; plant stress;

   Sammanfattning : Small heat shock proteins (sHsps) are found in all organisms and evolved early in the history of life, prior to the divergence of the three domains of life (Archaea, Bacteria, and Eukarya). Their malfunction is connected to several different diseases in humans, such as Alzheimer’s and Parkinson’s disease. LÄS MER

4. 28. Structural transitions of proton-gated ion channels : Involving pH sensing, heterogeneity and lipid interactions

   Författare :Urška Rovšnik; Erik Lindahl; Hugues Nury; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ion channels; cryo-electron microscopy; pH gating; simulations; structure-function relationship; GLIC; DeCLIC; biokemi; Biochemistry;

   Sammanfattning : Studying protein structure and function involves analyzing the relationship between a protein's three-dimensional assembly and its dynamic biochemical activity. The superfamily of pentameric ligand-gated ion channels (pLGICs) constitutes a classic yet illuminating experimental system for structure-function studies. LÄS MER

5. 29. Structural Studies of Glutamine Synthetases – Towards the Development of Novel Antitubercular Agents

   Författare :Wojciech W. Krajewski; Sherry L. Mowbray; Torsten Unge; Thomas C. Terwilliger; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Structural biology; Strukturbiologi;

   Sammanfattning : Glutamine synthetase (GS) plays an important role in nitrogen metabolism, where it catalyzes the ATP-dependent condensation of glutamate and ammonia to yield glutamine. Recent studies showed the importance of M. tuberculosis GS (MtGS) for growth and survival of the bacterium, and demonstrated its potential as a drug target. LÄS MER

7. 30. Structural characterisation of mitochondrial macromolecular complexes using cryo-EM : Mitoribosome biogenesis and respiratory chain supercomplex

   Författare :Sorbhi Rathore; Martin Ott; Daniel Wilson; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; mitoribosome biogenesis; mitoribosome assembly factors; yeast respiratory supercomplexes; single particle electron cryo-microscopy; cryo-EM sample preparation; Biochemistry; biokemi;

   Sammanfattning : Mitochondria, popularly known as powerhouse of the cell, contain specialised mitoribosomes that synthesise essential membrane proteins. These essential proteins are required to form enzyme complexes, which carry out the process of oxidative phosphorylation (OXPHOS). LÄS MER