Sökning: "mitoribosome biogenesis"

Hittade 5 avhandlingar innehållade orden mitoribosome biogenesis.

  1. 1. Structural characterisation of mitochondrial macromolecular complexes using cryo-EM : Mitoribosome biogenesis and respiratory chain supercomplex

    Författare :Sorbhi Rathore; Martin Ott; Daniel Wilson; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; mitoribosome biogenesis; mitoribosome assembly factors; yeast respiratory supercomplexes; single particle electron cryo-microscopy; cryo-EM sample preparation; Biochemistry; biokemi;

    Sammanfattning : Mitochondria, popularly known as powerhouse of the cell, contain specialised mitoribosomes that synthesise essential membrane proteins. These essential proteins are required to form enzyme complexes, which carry out the process of oxidative phosphorylation (OXPHOS). LÄS MER

  3. 2. Structure and Biogenesis of Membrane Proteins

    Författare :Mama Ndi; Martin Ott; Alexander Kastaniotis; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Cbp3; cytochrome b; respiratory complex III; alternative translation initiation and sodium proton exchange; Biochemistry; biokemi;

    Sammanfattning : Membrane proteins make up about one-third of the cellular proteome. The diverse roles that membrane proteins have in cells include major life-sustaining processes, making them major drug targets. LÄS MER

  4. 3. Characterization of GTPBPs involved in ribosome assembly and function in human mitochondria

    Författare :Miriam Cipullo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mitochondria are organelles often referred to as the powerhouses of the cell as they provide most of the chemical energy via aerobic respiration. However, in the last half a century, it has become clear that their function extends to other fundamental metabolic tasks. LÄS MER

  5. 4. The interactome of the yeast mitochondrial ribosome : Organization of mitochondrial post-transcriptional regulation, membrane protein insertion and quality control

    Författare :Braulio Vargas Möller-Hergt; Martin Ott; Michal Minczuk; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; mitochondrial post-transcriptional regulation; mitochondrial ribosome; membrane protein insertion; mitochondrial quality control; Biochemistry; biokemi;

    Sammanfattning : The proteins found in mitochondria originate from two different genetic systems. Most mitochondrial proteins are synthesized in the cytosol and post-translationally imported into the organelle. However, a small subset of mitochondrial proteins is encoded in an organelle-resident genome. LÄS MER

  7. 5. Structural and functional basis of mitochondrial tRNA processing

    Författare :Sagar Sridhara; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The mammalian mitochondria are subcellular organelles, generating energy in the cell by the synthesis of adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS). The maintenance of proper mitochondrial (mt) structure and function requires more than 1000 proteins generated from the nuclear DNA (nDNA) expression and 13 protein subunits generated from the mitochondrial DNA (mtDNA) expression. LÄS MER