Sökning: "DNA-binding proteins"
Visar resultat 1 - 5 av 137 avhandlingar innehållade orden DNA-binding proteins.
1. Characterization of the DNA-Binding Properties of the Cyanobacterial Transcription Factor NtcA
Sammanfattning : Nitrogen is an essential building block of proteins and nucleic acids and, therefore, crucial for the biosphere. Nearly 79 % of the air consists of nitrogen, but in the form of nitrogen gas (N2), which cannot be utilized by most organisms. LÄS MER
2. Structural Studies of Flexible Biomolecules and a DNA-binding Protein
Sammanfattning : The knowledge of the three-dimensional structures of proteins and polypeptides is essential to understand their functions. The work shown in this thesis has two objectives. LÄS MER
3. Protein–DNA Recognition : In Vitro Evolution and Characterization of DNA-Binding Proteins
Sammanfattning : DNA-recognizing proteins are involved in a multitude of important life-processes. Therefore, it is of great interest to understand the underlying mechanisms that set the rules for sequence specific protein–DNA interactions. Previous attempts aiming to resolve these interactions have been focused on naturally occurring systems. LÄS MER
4. Anti-gene oligonucleotides : DNA binding and therapeutic application
Sammanfattning : The field of nucleic acid therapeutics has in the last decade experienced substantial growth. This is evident from a multitude of new publications, an increasing number of clinical trials and several approved therapeutics on the market. LÄS MER
5. Biophysical studies of DNA binding – by the large filament-forming protein Rad51 and the small minor-groove binder Hoechst 33258
Sammanfattning : Mechanistic insight into the nature of DNA-binding ligands is crucial for both drug development as well as understanding more complex biological reactions that take place in the cell. In this Thesis, two rather different DNA-binding molecules are considered: 1. LÄS MER