Sökning: "Stable isotope labeling"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Stable isotope labeling.

  1. 1. Combined structural methods to characterize an oligomeric small heat shock protein Hsp21

    Författare :Gudrun Rutsdottir; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Small heat shock proteins; chaperones; crosslinking mass spectrometry; Stable isotope labeling; quantification; small angle X-ray scattering; cryo-electron microscopy; combined structural methods; plant stress;

    Sammanfattning : Small heat shock proteins (sHsps) are found in all organisms and evolved early in the history of life, prior to the divergence of the three domains of life (Archaea, Bacteria, and Eukarya). Their malfunction is connected to several different diseases in humans, such as Alzheimer’s and Parkinson’s disease. LÄS MER

  3. 2. Mass spectrometry for comparative proteomics of degenerative and regenerative processes in the brain

    Författare :Carina Sihlbom; Göteborgs universitet; []
    Nyckelord :glycoproteomics; quantitative proteomics; glycoprotein; protein quantification; glycosylation; Fourier transform ion cyclotron mass spectrometry; cerebrospinal fluid; Alzheimer s disease; neurodegeneration; neuroregeneration; hippocampus; astrocytes; brain injury; 14-3-3 protein; isoform;

    Sammanfattning : Biological processes involve changes at the protein level. Proteomics aims to determine protein changes from a normal state, to measure for instance recovery or disease progression. Mass spectrometry is the most important tool for identification of proteins and determination of post-translational modifications such as glycosylation. LÄS MER

  4. 3. Mass Spectrometry-based Neuroproteomics : Deciphering the Human Brain Proteome

    Författare :Sravani Musunuri; Jonas Bergquist; Ganna Shevchenko; Jean-Charles Sanchez; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Brain; Proteomics; Mass spectrometry; Alzheimer s disease; Traumatic brain injury; Membrane proteins; Sample preparation; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Mammalian brain is challenging to study due to its heterogeneity and complexity. However, recent advances in molecular imaging, genomics and proteomics have contributed significantly to achieve insights into molecular basis of brain function and pathogenesis of neurological disorders. LÄS MER

  5. 4. Phosphoproteomic analysis of Arabidopsis thaliana ribosomes

    Författare :Hanna Klang Årstrand; Alexander Vener; Cornelia Spetea Wiklund; Ingemar Rundquist; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Ribosomes serve as the site of protein synthesis in all living cells. Ribosomes were discovered in 1955 by George E. Palade when he was studying the endoplasmic reticulum which is covered by ribosomes. He received the Nobel Prize in Physiology or Medicine in 1974 for this discovery. LÄS MER

  7. 5. On tissue engineering of pig, human, and non-human primate tissues

    Författare :Nikhil Nayakawde; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Decellularization; esophagus; heart; larynx; proteomics; recellularization; SILAC; stem cells; tissue engineering;

    Sammanfattning : Background: Demand for donor organs for transplantation has been increasing every year more than the actual supply of suitable donor organs. One of the major problems associated with allogeneic transplantation includes lifelong immunosuppression. LÄS MER