Sökning: "splice variant"

Visar resultat 6 - 10 av 66 avhandlingar innehållade orden splice variant.

  1. 6. Mechanisms behind growth of castration-resistant prostate cancer bone metastases

    Författare :Emma Jernberg; Pernilla Wikström; Jack Schalken; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; castration-resistance; bone metastases; androgen receptor; intratumoral steroidogenesis; androgen receptor splice variants; androgen receptor amplification; patologi; Pathology;

    Sammanfattning : Background: The first-line treatment for patients with advanced prostate cancer (PC) is androgen deprivation therapy. This therapy is initially effective, but after some time tumors relapse, predominantly within the bone, and are then termed castration-resistant prostate cancer (CRPC). LÄS MER

  3. 7. Expression of thioredoxin reductase 1 in mammalian cells with regulation by the core promoter and use of alternative splice variants

    Författare :Anna-Klara Rundlöf; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Redox regulation; thioredoxin reductase; TXNRD1; selenoprotein; promoter; transcription; alternative splicing; expression;

    Sammanfattning : Reactive oxygen species are generated in cells as by-products of aerobic metabolism. To protect from damaging effects the cells possess several antioxidant systems and one of the most important is the thioredoxin system. LÄS MER

  4. 8. Oligonucleotide therapies for RNA and DNA : modulation of natural splice-variants, DNA structure and characterization of new synthetic nucleotides and reporter cell lines

    Författare :Cristina S J Rocha; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oligonucleotide therapy is an evolving field having shown fast and important developments in the last years. From genetics to metabolic, inflammatory, immunodeficiency diseases, cancer and viral infections the medical applications for this type of therapy are becoming broader every day. LÄS MER

  5. 9. The impact of estrogens on leukocyte function in remodeling of extracellular matrix

    Författare :Denis Stygar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Leukocyte; sex steroid hormones; estrogen; estrogen receptor; splice variant; extracellular matrix; remodeling; cervical ripening.;

    Sammanfattning : Background: Major reproductive events such as menstruation, ovulation, implantation and cervical ripening are characterized by an increased number of invading leukocytes in the tissues. Sex steroid hormones, particularly estrogens, play an important role in these changes. LÄS MER

  7. 10. Molecular complexities of patched signaling in cancer development

    Författare :Fahimeh Rahnama; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Basal Cell Carcinoma; Patched; Sonic Hedgehog; Desert Hedgehog; Splice variants; Skin;

    Sammanfattning : Basal Cell Cancer (BCC) is the most common cancer in the Western world. Although BCCs hardly ever metastasize, invasive growth may cause considerable local tissue destruction. BCCs mainly occur as sporadic tumors but can also be found in a hereditary form in the Nevoid Basal Cell Carcinoma Syndrome (NBCCS). LÄS MER