Sökning: "TXNRD1"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet TXNRD1.

1. 1. Expression of thioredoxin reductase 1 in mammalian cells with regulation by the core promoter and use of alternative splice variants

   Författare :Anna-Klara Rundlöf; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Redox regulation; thioredoxin reductase; TXNRD1; selenoprotein; promoter; transcription; alternative splicing; expression;

   Sammanfattning : Reactive oxygen species are generated in cells as by-products of aerobic metabolism. To protect from damaging effects the cells possess several antioxidant systems and one of the most important is the thioredoxin system. LÄS MER

3. 2. Mammalian thioredoxin reductase 1 in antioxidant defense, regulation of adipocyte differentiation and as an anticancer drug target

   Författare :Xiaoxiao Peng; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Reactive oxygen species (ROS) are oxygen containing reactive molecules generated as by-products of cellular metabolism. At physiological concentrations, ROS acts as secondary messengers in cellular signaling transduction, but excessive amounts of ROS result in oxidative stress and cellular damage. LÄS MER

4. 3. Plurifaceted proteomics in studying cellular dynamics and action mechanisms of anticancer drugs

   Författare :Pierre Sabatier; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Mass spectrometry (MS)-based proteomics has developed tremendously in recent years and was the leading technology for many novel methods to study protein chemistry. Contrary to classical approaches based on Western blot, MS-based approaches are mostly unbiased. LÄS MER

5. 4. Targeting glutathione peroxidases : identifying environmental modulators, and screening for novel small molecule inhibitors

   Författare :Dorian M. Cheff; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Glutathione peroxidases (GPXs) are a family of selenoproteins that are critical regulators of reactive oxygen species (ROS) in the cell, specifically hydroperoxides like hydrogen peroxide (H2O2). ROS are important for normal cell signaling and are tightly controlled to promote cell growth, proliferation, and survival. LÄS MER

7. 5. Thioredoxin reductase as a target enzyme for electrophilic anticancer drugs

   Författare :Sofi Eriksson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Induced production of reactive oxygen species (ROS) is a common attribute of most cancer cells. One strategy for cancer cells to maneuver the increased and potentially toxic levels of ROS is to induce the expression of cellular antioxidants and redox regulators, such as the thioredoxin (Trx) system. LÄS MER