Sökning: "splice variant"

Visar resultat 16 - 20 av 66 avhandlingar innehållade orden splice variant.

  1. 16. Genetic studies of non-HLA loci in rheumatoid arthritis : expression and interaction of candidate genes

    Författare :Marcus Ronninger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Genetic predisposition is an important contributor in development of human complex diseases, like rheumatoid arthritis (RA). In this thesis work, we present advances for involvement of non-HLA genetic risk factors for RA. LÄS MER

  3. 17. Gene silencing and expression during mammalian development : The special case of the imprinted H19 gene

    Författare :Kristian Svensson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Biologi; Biology; Biologi; zoologisk utvecklingsbiologi; Animal Development;

    Sammanfattning : Embryonic development consists of a vast number of fine-tuned, complex processesthat organise the body plan and individual organs. To enable developmental decisions,genes pivotal for normal development must be stably activated and silenced, asappropriate. LÄS MER

  4. 18. Studies on the Bcl-2 Family of Apoptosis Regulators in the Nervous System

    Författare :Susanne Hamnér; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Bcl-2; Bcl-w; Bad; Apoptosis; Nervous system; Cerebellar granule cells; Sympathetic neurons; Neurovetenskap; Neurology; Neurologi; Developmental Neurosciences; medicinsk utvecklings- och neurobiologi;

    Sammanfattning : Apoptosis is a type of cell death with a specific morphology and molecular program, which is essential for the development of the nervous system. However, inappropriate cell death has been implicated in several neurodegenerative diseases. LÄS MER

  5. 19. Studies on the transmembrane signaling of β1 integrins

    Författare :Annika Armulik; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Integrin β1; signaling; transmembrane domain; CAS; focal adhesion kinase; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Integrins are heterodimeric cell surface receptors, composed of an α and a β subunit, mainly binding for extracellular matrix proteins. lntegrin subunit β1 can combine with at least 12 a subunits and thus form the biggest subfamily within the integrin family. LÄS MER

  7. 20. Role of Heparan Sulfate N-sulfation in Mouse Embryonic Development

    Författare :Anders Dagälv; Lena Kjellén; Svein Kolset; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heparan sullfate; heparin; proteoglycan; NDST1; NDST2; coreprotein; syndecan; Biochemistry; Biokemi; Cell biology; Cellbiologi; Biokemi; Biochemistry;

    Sammanfattning : Heparan sulfate (HS) is a sulfated glycosaminoglycan expressed by all cells in the body. It is found at the cell surface and in the extracellular matrix where it binds a large amount of various ligands including growth factors and morphogens. LÄS MER