Sökning: "castration-resistance"
Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet castration-resistance.
1. Mechanisms behind growth of castration-resistant prostate cancer bone metastases
Sammanfattning : Background: The first-line treatment for patients with advanced prostate cancer (PC) is androgen deprivation therapy. This therapy is initially effective, but after some time tumors relapse, predominantly within the bone, and are then termed castration-resistant prostate cancer (CRPC). LÄS MER
2. Evaluation of regulator of G-protein signaling 2 (RGS2) at different stages of prostate cancer - Significance and clinical potential
Sammanfattning : Prostate cancer (PC) is often a slow-growing and symptom-free disease with good prognosis. However, a substantial number will progress, ultimately metastasize if left untreated and finally kill the patient. The standard treatment for these stages of PC is androgen deprivation therapy (ADT), which generally has an initially good clinical response. LÄS MER
3. Galiellalactone Synthetic Studies
Sammanfattning : In search for remedies and treatments, science has recurred to Mother Nature. This is where galiellalactone was found, a fungal metabolite isolated from Galiella rufa in 1990. Since then chemists and biologists have been studying its properties and found it to be a potential candidate against castration-resistance prostate cancer (CRPC). LÄS MER
4. The regulatory role of osteoblasts in castration-resistant growth of prostate cancer
Sammanfattning : Bone metastasis of a predominantly osteoblastic (sclerotic) nature is the outcome for the vast majority of patients with castration-resistant prostate cancer (CRPC). Pathologically, osteoblastic tumors are characterized by excessive bone formation resulting in decreased quality of life due to severe pain, fractures, nerve compression, and a suppressed immune system. LÄS MER
5. A study of two major challenges in prostate cancer : effective chemo-prevention and overcoming resistance to hormonal and chemotherapy
Sammanfattning : For men, over the course of a lifetime the risk of developing prostate cancer is 1 in 9. Both the illness itself and treatment affect quality of life in multiple aspects, including urinary problems, pain, and sexual dysfunction. LÄS MER