Sökning: "splice variant"
Visar resultat 11 - 15 av 66 avhandlingar innehållade orden splice variant.
11. The role of human cytomegalovirus infection in cancer
Sammanfattning : Cancer is a major cause of morbidity and mortality worldwide. It is thought that up to 20% of cancers are caused by infectious agents, and an oncogenic role of several viruses has been established for certain tumours. Increasing evidence implies that human cytomegalovirus (HCMV) infection is associated with a number of malignancies. LÄS MER
12. Alternative splicing of interleukin-7
Sammanfattning : Alternative splicing of pre-mRNA is the primary source of creating proteome diversity in humans; it is therefore highly relevant to disease and therapy. Alternative splicing has been described for many cytokines and these splice variants appear to function as either agonists or as antagonists of the wildtype cytokine. LÄS MER
13. Cellular design of heparan sulfate : The NDST enzymes and their regulation
Sammanfattning : Heparan sulfate proteoglycans are proteins with long, unbranched heparan sulfate (HS) polysaccharide chains attached to them. They are found on cell surfaces and in basement membranes where they exert their action by interacting with a wide range of enzymes and signaling molecules and are thereby involved in a range of various processes both during embryonic development and in adult physiology. LÄS MER
14. Underlying genetic mechanisms of hereditary dystrophies in retina and cornea
Sammanfattning : Inherited retinal and corneal dystrophies represent a group of disorders with great genetic heterogeneity. Over 250 genes are associated with retinal diseases and 16 genes are causative of corneal dystrophies. LÄS MER
15. Multivariate analysis of cancer proteomics data : towards a biological systems view and understanding
Sammanfattning : Important aims of cancer proteomics include gaining better understanding of cancer biology and identifying cancer biomarkers. Mass spectrometry (MS) based shotgun proteomics allow for identification and quantification of thousands of proteins in complex human samples. LÄS MER