Sökning: "signal transduction molecules"

Visar resultat 21 - 25 av 68 avhandlingar innehållade orden signal transduction molecules.

  1. 21. Natural and induced idiotype immunity in patients with multiple myeloma

    Författare :Lotta Hansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Myeloma; idiotype; vaccination; GM-CSF; IL-12; clonal B cells; T cell epitopes; signal transduction molecules; activation markers;

    Sammanfattning : There is a great need for development of new treatment alternatives for patients with multiple myeloma (MM). The idiotype (Id) immunoglobulin (Ig) expressed by the myeloma B cell clone might be regarded as a tumor specific antigen and as such a target for immunotherapy. LÄS MER

  3. 22. Dynamic regulation of the Mig1 transcriptional repressor under glucose de/repression

    Författare :Sviatlana Shashkova; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell signalling; glucose repression; Mig1; phosphorylation; Saccharomyces cerevisiae;

    Sammanfattning : The budding yeast Saccharomyces cerevisiae AMP-activated protein kinase/SNF1 is a member of a highly conserved protein family present in all eukaryotes. Snf1 regulates energy homeostasis; in yeast, it is best-known for its role in cellular adaptation to glucose limitation. LÄS MER

  4. 23. Oxidative stress and calcium signalling : implications for diabetes and cardiac glycosides

    Författare :Mark Lal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Calcium; diabetes; Na; K-ATPase; ouabain; oxidative stress;

    Sammanfattning : The signal transduction processes by which an individual cell is able to recognize and respond to its external environment are critical to determining its survival as well as that of the entire organism. In the current study we have investigated the intracellular signalling cascades activated downstream of two separate stimuli: the diabetic milieu and the cardiac glycoside, ouabain. LÄS MER

  5. 24. Molecular and functional studies of the BCR/ABL1 fusion gene

    Författare :Petra Johnels; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Hematologi; Haematology; onkologi; Cytologi; cancerology; oncology; Cytology; gene expression profiling; acute lymphoblastic leukemia; chronic myeloid leukemia; Ph chromosome; BCR ABL; extracellulära vätskor; Clinical genetics; Klinisk genetik; cancer;

    Sammanfattning : The BCR/ABL1 fusion gene is associated with chronic myeloid leukemia and a subgroup of acute lymphoblastic leukemia. The general aim of this thesis was to increase the understanding of BCR/ABL1-induced leukemogenesis by molecular and functional studies of this fusion gene. LÄS MER

  7. 25. Ligand-receptor interactions and signaling cross-talk in the TGF-b superfamily

    Författare :Andries Blokzijl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The transforming growth factor-beta (TGF-beta) superfamily of secreted polypeptide growth factors forms part of an evolutionary conserved signaling pathway, present in diverse organisms from flies to humans, used in intercellular communication. The TGF-beta family comprises more than 40 members in vertebrates, Caenorhabditis elegans and Drosophila melanogaster. LÄS MER