Sökning: "Myeloma"

Visar resultat 1 - 5 av 95 avhandlingar innehållade ordet Myeloma.

  1. 1. Epidemiological studies on multiple myeloma

    Författare :Mikael Eriksson; Lennart Hardell; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; multiple myeloma; epidemiology; farming; domestic animals; phenoxyacetic adds; DDT; rheumatoid arthritis; familial factors;

    Sammanfattning : Multiple myeloma is a painful and uncurable malignant disease with an increasing incidence and mortality in several countries, e.g., Sweden. Some factors are suspected to be of aetiological significance, such as ionising radiation and chronic antigenic stimulation in certain inflammatory diseases. LÄS MER

  2. 2. Apoptosis Regulation in Multiple Myeloma

    Författare :Lina Dimberg; Helena Jernberg Wiklund; Kenneth Nilsson; Marie Arsenian Henriksson; Uppsala universitet; []
    Nyckelord :Biomedicine; multiple myeloma; apoptosis; survival; IFN; Stat1; Stat3; IGF-I; RTK inhibitor; PPP; IAP; Fas CD95; dexamethasone; Biomedicin;

    Sammanfattning : Multiple myeloma (MM) is a virtually incurable B cell malignancy of the bone marrow. One important part of tumor progression and an obstacle for successful therapy is resistance to apoptosis. To combat this resistance, the mechanisms of apoptosis and survival in MM must be better defined. LÄS MER

  3. 3. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation

    Författare :Alba Atienza Párraga; Helena Jernberg-Wiklund; Fredrik Öberg; Antonia Kalushkova; Miguel Angel Peinado; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; epigenetics; Polycomb; EZH2; miRNA; DNA methylation; inhibitor.; Experimentell patologi; Experimental Pathology;

    Sammanfattning : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. LÄS MER

  4. 4. Aspects of Phagocyte Function in Multiple Myeloma

    Författare :Stina Wichert; Myelomgruppen; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; Phagocyte function; ASCT; Eosinophils; CXCR4; anti-ICAM-1 monoclonal antibody; BI-505; Phase 2 trial;

    Sammanfattning : .... LÄS MER

  5. 5. Regulation of apoptosis in human multiple myeloma

    Författare :Helena Spets; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; apoptosis; multiple myeloma; IL-6; Bcl-2; Fas; dexamethasone; IGF-I; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Multiple myeloma (MM) is a clonal expansion of malignant plasmablasts-plasma cells in the bone marrow. MM is slowly proliferating and an increased resistance to apoptosis may be crucial for the tumor progression. LÄS MER