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Visar resultat 6 - 10 av 237 avhandlingar som matchar ovanstående sökkriterier.

1. 6. ARCON in experimental and clinical radiotherapy

   Författare :Ana Maria Rojas Callejas; Björn Zackrisson; René-Olivier Mirimanoff; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; ARCON; tumours; normal tissues; radiosensitization; carbogen; nicotinamide; repair inhibition; therapeutic gain; rodents; humans; Onkologi; Oncology; Onkologi; onkologi; Oncology;

   Sammanfattning : xHypoxia and repopulation of tumour clonogens are two important determinants of treatment outcome in radiotherapy. In general clinical evidence indicates that loco-regional control may be reduced with long overall treatment times and for tumours with low pre-treatment levels of oxygen. LÄS MER

3. 7. The zoo-geomorphological impact of fossorial rodents in sub-polar alpine environments

   Författare :Bert Eriksson; Jan Boelhowers; John Östh; Hanna Ridefelt; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; zoo-geomorphology; fossorial rodents; sub-polar; alpine; geomorphic work; ecosystem engineers; Physical geography; Naturgeografi; Geography; Geografi;

   Sammanfattning : The geomorphological impact of small fossorial mammals (adapted to digging and living underground), such as rodents can be significant, and both their direct and indirect effects may contribute to landscape formation. This thesis is based on empirical field studies of two burrowing rodent species in sub-polar environments, namely invasive House mice (Mus musculus) on sub-Antarctic Marion Island and Norwegian lemmings (Lemmus lemmus) in sub-Arctic Abisko. LÄS MER

4. 8. Cytokine regulation in rodents with experimental arthritis

   Författare :Åsa Boström Müssener; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :collagen-induced arthritis; oil-induced arthritis; IL-2; IL-4; TNFa; IFNy; TGFß;

   Sammanfattning : The general aim of this project has been to try to elucidate the mechanisms behind induction of arthritis by using in situ hybridization and immunohistochemical methods to analyse the dynamics of the cytokine network in vivo, in the peripheral Iymphoid system and in the joints of rodents with collagen-induced arthritis (CIA)and oil-induced arthritis (OIA). We first examined the kinetics of cytokine gene expression in vivo, in the draining Iymph nodes of DA rats following immunization with rat type II collagen (RCII) emulsified in Freund's incomplete adjuvant oil (FIA) or with only FIA, which are regimens that induce CIA and OIA, respectively. LÄS MER

5. 9. The genetics of experimental arthritis in rodents

   Författare :Michael Förster; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Unravelling the genetic susceptibility to complex autoimmune diseases and understanding these pathologies on a mechanistic level are major obstacles to improve our possibilities for therapeutic intervention and an increase in the quality of life of affected patients. Studies in experimental rodent models, that can be run under stable environmental conditions, which itself can be subjected to experimental manipulation, and in cohorts of potentially unlimited size, hold significant promise for the understanding of genes and pathways involved in complex autoimmune diseases. LÄS MER

7. 10. Tissue specificity of N-nitrosamine metabolism : studies in pregnant and non-pregnant rodents

   Författare :Boël Löfberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

   Sammanfattning : .... LÄS MER