Sökning: "responsive regulation"

Visar resultat 21 - 25 av 138 avhandlingar innehållade orden responsive regulation.

  1. 21. Studies on the transcriptional regulation of sterol 12alpha-hydroxylase (CYP8B1)

    Författare :Yizeng Yang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bile acids; CYP8B1; CYP7A1; transcription; nuclear receptor; PPAR-alpha; HNF4-alpha; FTF; SREBP; thyroid hormones.;

    Sammanfattning : The conversion of cholesterol into bile acids is mainly via two pathways, which are initiated by CYP7A1 and CYP27A1 respectedly. CYP8B1, a microsomal P450 cytochrome, hydroxylates of the steroid nucleus at the C-12alpha position to form 7alpha, 12alpha-dihydroxy-4-cholesten-3-one, a facultative precursor of CA. LÄS MER

  3. 22. Deciphering control of Mechano-Transcription Activators of σ54-RNA polymerase

    Författare :Henrik Seibt; Victoria Shingler; Uwe H. Sauer; Ray Dixon; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transcriptional regulation; P. putida; V. cholerae; AAA ; bEBP; B-linker; DmpR; Phenol catabolism; VCA0117; Type VI secretion; molekylärbiologi; Molecular Biology;

    Sammanfattning : To survive and proliferate, bacteria have to respond to a plethora of fluctuating signals within their habitats. Transcriptional control is one crucial entry point for such signal-responsive adaption responses. LÄS MER

  4. 23. Controlling virulence in Yersinia pseudotuberculosis through accumulation of phosphorylated CpxR

    Författare :Edvin Thanikkal; Matthew Francis; Andrew Darwin; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Y. pseudotuberculosis; CpxA; CpxR; invasin; RovA; RovM; T3SS; virulence; transcriptional regulation; molekylärbiologi; Molecular Biology; mikrobiologi; Microbiology;

    Sammanfattning : Like many Gram-negative bacteria, the food-borne pathogen Yersinia pseudotuberculosis harbours different regulatory mechanisms to maintain an intact bacterial envelope especially during exposure to extracytoplasmic stress (ECS). The CpxA-CpxR two component regulatory system is one such ECS-responsive regulatory mechanism. LÄS MER

  5. 24. Epigenetic Regulation of Light and Hormonal Signaling in Arabidopsis thaliana

    Författare :Kristina Rizzardi; Annika Sundås-Larsson; Katarina Landberg; Johan Memelink; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TERMINAL FLOWER2; auxin; jasmonate; epigenetics; photomorphogenesis; Plant physiology; Växtfysiologi; Biologi med inriktning mot fysiologisk botanik; Biology with specialization in Physiological Botany;

    Sammanfattning : Plants are stationary and need to adapt to the environment they live in. Integration of environmental cues, such as changes in light and temperature, can occur either directly or through the action of hormones. Hormone and light signaling leads to rapid changes in gene expression, and eventually changes in protein levels. LÄS MER

  7. 25. Mechanism of conditional regulation of the bHLH/PAS dioxin receptor

    Författare :Jacqueline McGuire; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The intracellular dioxin receptor is a bHLH/PAS protein which mediates signal transduction by dioxin and upon heterodimerisation with the bHLH/PAS partner factor Arnt, functions as a ligand-activated transcription factor by binding to specific xenobiotic response elements in promoters of target genes. Although the physiological function of the dioxin receptor and the nature of a possible physiological ligand are presently not known, targeted disruption of the mouse dioxin receptor gene has indicated that the receptor may play an important role in hepatic development. LÄS MER