Sökning: "Victoria Shingler"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Victoria Shingler.
1. On the role of ppGpp and DksA mediated control of σ54-dependent transcription
Sammanfattning : The σ54-dependent Po promoter drives transcription of an operon that encodes a suite of enzymes for (methyl)phenols catabolism. Transcription from Po is controlled by the sensor-activator DmpR that binds (methyl)phenol effectors to take up its active form. LÄS MER
2. On the role of small regulatory molecules in the interplay between σ54- and σ70-dependent transcription
Sammanfattning : Signal responsive transcriptional control in bacteria is mediated through both specific and global regulatory circuits to attune promoter output to prevailing conditions. Divergent transcription of a regulatory gene and a cognate promoter under its control provides an opportunity for interplay between transcription dependent on RNA polymerases utilizing various σ-factors, each of which programs the holoenzyme to recognize different classes of promoters. LÄS MER
3. Multiple regulatory inputs for hierarchical control of phenol catabolism by Pseudomonas putida
Sammanfattning : Metabolically versatile bacteria have evolved diverse strategies to adapt to different environmental niches and respond to fluctuating physico-chemical parameters. In order to survive in soil and water habitats, they employ specific and global regulatory circuits to integrate external and internal signals to counteract stress and optimise their energy status. LÄS MER
4. Bioinformatics, evolution and revolution in our understanding of toxin-antitoxin systems
Sammanfattning : Bacteria experience a wide range of natural challenges during their life cycles, to which they must respond and adapt to live. Under stressed conditions such as amino acid starvation, bacteria slow down their growth mechanism by producing small alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively referred to as (p)ppGpp. LÄS MER
5. Deciphering control of Mechano-Transcription Activators of σ54-RNA polymerase
Sammanfattning : To survive and proliferate, bacteria have to respond to a plethora of fluctuating signals within their habitats. Transcriptional control is one crucial entry point for such signal-responsive adaption responses. LÄS MER