Sökning: "Yizeng Yang"

Hittade 1 avhandling innehållade orden Yizeng Yang.

1. 1. Studies on the transcriptional regulation of sterol 12alpha-hydroxylase (CYP8B1)

   Författare :Yizeng Yang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Bile acids; CYP8B1; CYP7A1; transcription; nuclear receptor; PPAR-alpha; HNF4-alpha; FTF; SREBP; thyroid hormones.;

   Sammanfattning : The conversion of cholesterol into bile acids is mainly via two pathways, which are initiated by CYP7A1 and CYP27A1 respectedly. CYP8B1, a microsomal P450 cytochrome, hydroxylates of the steroid nucleus at the C-12alpha position to form 7alpha, 12alpha-dihydroxy-4-cholesten-3-one, a facultative precursor of CA. LÄS MER