Sökning: "reperfusion injury"

Visar resultat 41 - 45 av 96 avhandlingar innehållade orden reperfusion injury.

  1. 41. Studies of myocardial ischaemia followed by reperfusion : new experimental models and their application

    Författare :Yozo Uriuda; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :myocardial infarction; myocardial ischaemia; reperfusion injury; animal experiment; rat; pig; dog; coronary venous retroinfusion; synchronised coronary venous retroperfusion; thrombosis; thrombolysis; inogatran; endothelin;

    Sammanfattning : Despite great efforts to reduce morbidity and mortality in ischaemic heart disease, this is still the most common cause of death in the industrialised countries. To improve the management of such patients, further knowledge is needed of the pathophysiology of ischaemic heart disease. LÄS MER

  3. 42. The role of endothelin during myocardial ischaemia and reperfusion : pathophysiological mechanisms and interactions with nitric oxide

    Författare :Adrian T Gonon; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ischaemia; reperfusion injury; myocardium; infarct size; endothelium; endothelin; endothelin receptor; nitric oxide; nitric oxide synthase; polymorphonuclear leukocytes; myeloperoxidase; pig; rat;

    Sammanfattning : Acute myocardial infarction followed by reperfusion results in accelerated necrosis of irreversibly injured myocytes as well as induction of lethal injury to reversibly injured cells. Polymorphonuclear leukocytes (PMNs) are major participants in the reperfusion-initiated inflammation. LÄS MER

  4. 43. Focal ischemic reperfusion stroke model in rats and the role of galanin

    Författare :Lovisa Holm; Annette Theodorsson; Elvar Theodorsson; Tomas Hökfelt; Yanlin Wang-Fischer; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Stroke is the third most common cause for mortality in industrialised countries and amongst the major causes of long- time morbidity. While the mortality due to myocardial infarction has been dramatically reduced during the last 10-15 years, mortality due to stroke remains almost the same, despite the fact that the two share similar basic pathogenic mechanisms including atherosclerosis, hypertension and diabetes. LÄS MER

  5. 44. Myocardial ischemia-reperfusion and cardioprotection. A study with microdialysis in a porcine model

    Författare :Carsten Metzsch; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heart preservation; metoprolol; levosimendan; beta-blockers; pharmacological preconditioning; myocardial ischemia; cardioprotection; glycerol; microdialysis; cold cardioplegic storage;

    Sammanfattning : The studies in this thesis are based on questions raised in the clinical setting. Perioperative myocardial ischemia occurs more often than recognized. This may lead to myocardial infarction, increased morbidity, mortality, and health care costs. LÄS MER

  7. 45. Intrarenal oxygen homeostasis in acute and chronic kidney disease

    Författare :Oskar Nensén; Fredrik Palm; Börje Haraldsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; acute kidney injury; oxygen; kidney disease; renal physiology; Fysiologi; Physiology;

    Sammanfattning : Renal hypoxia has been recognized as a common feature of acute and chronic kidney injury arising from varying etiologies. It has also been proposed to provide a driving mechanism for the transition from acute to chronic kidney disease (CKD). LÄS MER