Sökning: "pharmacological preconditioning"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden pharmacological preconditioning.

  1. 1. DNA repair and the p53 pathway in ischemic and traumatic brain injury

    Författare :Gregor Tomasevic; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuronal death; DNA repair; knock-out mice; XPA; p53; mRNA; hippocampus; preconditioning; hypothermia; trauma; Brain; ischemia; neurobehavior; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Ischemic and traumatic brain damage are major causes of disability and death. While much effort has been spent to develop pharmacological treatments for these conditions, no neuroprotective drugs are in clinical use. LÄS MER

  3. 2. Experimental Traumatic Brain Injury and Cell Death - in vivo and in vitro aspects

    Författare :Gustav Mattiasson; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurofysiologi; neuropsychology; Neurology; uncoupling protein; mitochondrial permeability transition; cerebral blood flow; functional outcome; cell death; mitochondria; hippocampus; preconditioning; trauma; Brain; ischemia; neuropsykologi; Neurologi; neurophysiology;

    Sammanfattning : Traumatic and ischemic brain damage are major causes of disability and death. While much effort has been spent on developing pharmacological treatments for these conditions, no neuroprotective drugs are in clinical use. LÄS MER

  4. 3. Myocardial ischemia-reperfusion and cardioprotection. A study with microdialysis in a porcine model

    Författare :Carsten Metzsch; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heart preservation; metoprolol; levosimendan; beta-blockers; pharmacological preconditioning; myocardial ischemia; cardioprotection; glycerol; microdialysis; cold cardioplegic storage;

    Sammanfattning : The studies in this thesis are based on questions raised in the clinical setting. Perioperative myocardial ischemia occurs more often than recognized. This may lead to myocardial infarction, increased morbidity, mortality, and health care costs. LÄS MER

  5. 4. The importance of nitric oxide bioavailability and endothelial mechanisms for cardioprotection by pharmacological intervention during myocardial ischaemia and reperfusion

    Författare :Andrey Gourine; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ATP sensitive K channels; endothelin-1; clevidipine; ETA receptor antagonist; glibenclamide; 5-hydroxydecanoic acid; infarct size; ischaemia; myeloperoxidase; nitric oxide; nitric oxide synthase; pig; preconditioning; rat; reperfusion.;

    Sammanfattning : Myocardial ischaemia initiates complex severe cellular changes and, after a critical time period, myocardial cell death. Despite that restitution of coronary blood flow is an absolute pre-requisite for tissue survival, myocardial reperfusion per se will also increase irreversible damage in the jeopardised myocardium. LÄS MER

  7. 5. Modifications of cardiovascular response to ischemia and trauma

    Författare :Fausto Labruto; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ischemia; trauma; cardiovascular function; preconditioning;

    Sammanfattning : Ischemia and trauma are two clinical problems characterized by a common response: inflammation and potentially deleterious effects on the organism. Surgery is a form of trauma, and the most advanced surgical operations, including open heart surgery, aortic surgery, and organ transplantation, cause trauma and ischemia of the cardiovascular system. LÄS MER