Sökning: "levosimendan"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet levosimendan.

  1. 1. Levosimendan in early experimental sepsis: effects on the heart and hepatosplanchnic circulation

    Författare :Doris Cunha Goncalves; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; septic shock; myocardial oxygen consumption; myocardial dysfunction; levosimendan; endotoxin; contractility; catecholamines; calcium sensitizer; cardiotonic agents; splanchnic perfusion;

    Sammanfattning : Sepsis-related cardiovascular dysfunction associated with fluid-unresponsive tissue hypoperfusion might require inotropic treatment. This cardiovascular dysfunction seems to involve calcium desensitization and adrenergic unresponsiveness. LÄS MER

  3. 2. Levosimendan vs. Milrinone: Early Renal and Hemodynamic Outcomes after lnfant Cardiac Surgery

    Författare :Elin M. Thorlacius; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cardiac surgery; infants; congenital heart lesions; levosimendan; milrinone; acute kidney injury; myocardial function; biomarkers;

    Sammanfattning : Background: Myocardial and renal dysfunction are common after cardiac surgery in young children, which increases risk of complications and delayed recovery. Inodilators, such as milrinone and levosimendan, are frequently used to reduce the risk of low cardiac output syndrome in infants after cardiac surgery. LÄS MER

  4. 3. Cardiac effects of non-adrenergic inotropic drugs : clinical and experimental studies

    Författare :Birger Axelsson; Michael Haney; Hans Tydén; Anil Gupta; Patrick Wouters; Sven-Erik Ricksten; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Milrinone; levosimendan; vein graft flow; myocardial ischemia; protection; inotropy; diastole; Anaesthesiology; anestesiologi;

    Sammanfattning : Background: Myocardial failure and dysfunction is not uncommon during critical illness and following cardiac surgery. For optimal treatment, a better understanding of the effects of inotropic drugs is needed. In this thesis, two non-adrenergic mediated inotropes, milrinone and levosimendan were studied in different models of myocardial dysfunction. LÄS MER

  5. 4. Cardiac surgery and the kidney - studies on the effects of pharmacological interventions on renal perfusion, filtration and oxygenation

    Författare :Gudrun Bragadottir; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney failure; acute; glomerular filtration rate; renal circulation; oxygen consumption; cardiac surgery; vasopressin; mannitol; levosimendan; estimating equations;

    Sammanfattning : Acute kidney injury (AKI) commonly complicates cardiac surgery and is associated with high mortality. Renal ischemia is considered to be the major cause. There is a close association between glomerular filtration rate (GFR), tubular sodium reabsorption and renal oxygen consumption (RVO2) in humans. LÄS MER

  7. 5. Myocardial ischemia-reperfusion and cardioprotection. A study with microdialysis in a porcine model

    Författare :Carsten Metzsch; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heart preservation; metoprolol; levosimendan; beta-blockers; pharmacological preconditioning; myocardial ischemia; cardioprotection; glycerol; microdialysis; cold cardioplegic storage;

    Sammanfattning : The studies in this thesis are based on questions raised in the clinical setting. Perioperative myocardial ischemia occurs more often than recognized. This may lead to myocardial infarction, increased morbidity, mortality, and health care costs. LÄS MER