Sökning: "regulatory RNA"

Visar resultat 1 - 5 av 267 avhandlingar innehållade orden regulatory RNA.

  1. 1. RNA-mediated gene expression regulation

    Författare :Paula Petronela Groza; Francesca Aguilo; Yuri B. Schwartz; Silvia Remeseiro; Henrik Nielsen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA modifications; fibrillarin; 2 -O-methylation; translation; alternative splicing; METTL3; m6A; ZFP207; breast cancer; mouse ESCs; molekylärbiologi; Molecular Biology;

    Sammanfattning : The regulation of gene expression is a key mechanism that underlies all biological processes, from embryonic development to the onset and progression of various diseases, including cancer. A growing body of evidence places RNA molecules at the center of critical regulatory steps in gene expression. LÄS MER

  3. 2. CopA and CopT: The Perfect RNA Couple

    Författare :Jacoba G. Slagter-Jäger; Gerhart Wagner; Wolfgang Nellen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microbiology; antisense RNA; plasmid; U-turn; four-way junction; RNA-RNA interaction; Hfq; Mikrobiologi; Microbiology; Mikrobiologi; mikrobiologi; Microbiology;

    Sammanfattning : Antisense RNAs regulate gene expression in many bacterial systems. The best characterized examples are from prokaryotic accessory elements such as phages, plasmids and transposons. Many of these antisense RNAs have been identified as plasmid copy number regulators where they regulate the replication frequency of the plasmid by negative feedback. LÄS MER

  4. 3. Multifaceted RNA-mediated regulatory mechanisms in Streptococcus pyogenes

    Författare :Anaïs Le Rhun; Emmanuelle Charpentier; Franz Narberhaus; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Streptococcus pyogenes; small RNAs; CRISPR; Cas9; tracrRNA; RNases; gene expression; RNA sequencing; Infectious Diseases; infektionssjukdomar; mikrobiologi; Microbiology;

    Sammanfattning : Bacterial pathogens rely on precise regulation of gene expression to coordinate host infection processes and resist invasion by mobile genetic elements. An interconnected network of protein and RNA regulators dynamically controls the expression of virulence factors using a variety of mechanisms. LÄS MER

  5. 4. Regulation of RNA Editing : The impact of inosine on the neuronal transcriptome

    Författare :Mikaela Behm; Marie Öhman; André Gerber; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; RNA editing; ADAR; miRNA; Neuron; Brain development; Synapse; Molecular Biology; molekylärbiologi;

    Sammanfattning : The transcriptome of the mammalian brain is extensively modified by adenosine to inosine (A-to-I) nucleotide conversion by two adenosine deaminases (ADAR1 and ADAR2). As adenosine and inosine have different base pairing properties, A-to-I RNA editing shapes the functional output of both coding and non-coding RNAs (ncRNAs) in the brain. LÄS MER

  7. 5. Regulatory Roles of Noncoding RNA in Development and Disease

    Författare :Gaurav Kumar Pandey; Chandrasekhar Kanduri; Claes Wadelius; Karl Ekwall; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Noncoding RNA; Genomic Imprinting; Epigenetics; Neuroblastoma;

    Sammanfattning : Long noncoding RNAs (lncRNAs) are being realized as important players in gene regulation and their misregulation has been considered as one of the underlying causes for tumor initiation and progression in many human pathologies. In the current thesis, I have addressed the functional role of lncRNAs in development and disease model systems. LÄS MER