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Visar resultat 1 - 5 av 26 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Regulated Proteolysis: The Secrets of Lon : Cellular Roles and Stress-dependent Regulation of the Lon Protease

    Författare :Matthias J. Fink; Kristina Jonas; Axel Mogk; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Lon protease; regulated proteolysis; allosteric regulation; Caulobacter crescentus; stress responses; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Proteolysis is crucial in cells to maintain a functional proteome. It is required for removal of damaged and unfolded proteins during protein quality control, and serves as a mechanism to regulate protein levels through regulated proteolysis. LÄS MER

  3. 2. The cell biology and catalytic properties of the nutrient-induced signaling endoprotease Ssy5

    Författare :António Martins; Per O. Ljungdahl; Bruno André; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nutrient sensing; signal transduction; regulated proteolysis; endoprotease; serine protease; substrate specificity; subcellular fractionation; Saccharomyces cerevisiae; Cell Biology; cellbiologi;

    Sammanfattning : Cells continuously sense and respond to changes in the presence, quality and quantity of external and internal nutrients. Specific signaling proteases have been identified based on their roles in processing or destruction of distinct sets of downstream effector proteins in response to environmental cues. LÄS MER

  4. 3. Ligand-activated proteolysis in nutrient signaling

    Författare :Claes Andréasson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cells respond to changing nutrient availability and make adjustments in physiological processes. Central for making proper adjustments is the ability to execute appropriate changes in patterns of gene expression. LÄS MER

  5. 4. Design and Synthesis of Angiotensin IV Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP)

    Författare :Hanna Andersson; Anders Hallberg; Anders Karlén; Federico Corelli; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; angiotensin IV; AT4; insulin-regulated aminopeptidase IRAP ; inhibitor; peptidomimetics; γ-turn mimetic; macrocycle; Pharmaceutical chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Peptidomimetics derived from the bioactive hexapeptide angiotensin IV (Ang IV, Val1-Tyr2-Ile3-His4-Pro5-Phe6) have been designed and synthesized. These peptidomimetics are aimed at inhibiting the insulin-regulated amino peptidase (IRAP), also known as the AT4 receptor. LÄS MER

  7. 5. Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis

    Författare :Lei Lu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Proteasome; Ubiquitin; Cancer; Neuro-degeneration; Poly-Glutamine; Apoptosis; Tripeptidyl-Peptidase II; Stress; IAP;

    Sammanfattning : The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates are degraded by the 26S proteasome, a large multicatalytic protease complex. LÄS MER