Sökning: "proteoglycan fragment"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden proteoglycan fragment.

  1. 1. Proteoglycan Lectin Domain Interactions in Extracellular Matrix Assembly

    Författare :Anders Olin; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper allmänt ; General biomedical sciences; crystal structure; network formation; collagen IX; N-glycans; PRELP; cross-linking; fibulin-2; lectin; G3; ECM; proteoglycan;

    Sammanfattning : This thesis focuses on the C-terminal G3 region of the large aggregating proteoglycans that are found in complex with hyaluronan in the extracellular matrix. The G3 region contains a C-type lectin domain that binds different extracellular matrix proteins playing an integral role in tissue organization during development and remodeling. LÄS MER

  3. 2. Maturation-dependent normal and injury-induced changes in rabbit knee articular cartilage

    Författare :Xiaochun Wei; Leif Ryd; Linköpings universitet; []
    Nyckelord :rabbit; development; maturation; knee joint; articular cartilage; osteochondral defect; cartilage repair; joint fluid; subchondral bone volume fraction; proteoglycan fragment; transforming growth factor-ß; biomechanics; indentation; histology; hlstomorphometry; MEDICINE; MEDICIN;

    Sammanfattning : Cartilage injuries are common in sports, and may on the long term develop to osteoarthritis. Prosthetic joint replacement is not satisfactory for young active individuals with extended cartilage injuries in large weight-bearing joints. In these cases, a treatment is needed which reestablishes normal joint surfaces by biologic means. LÄS MER

  4. 3. Aggrecan fragments as biomarkers in osteoarthritis

    Författare :Staffan Larsson; Lund Ortopedi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protease; Aggrecan; osteoarthritis; proteoglycan; knee injury; biomarker; aggrecanase;

    Sammanfattning : Background: In osteoarthritis (OA) the balance of cartilage matrix synthesis and degradation is disturbed, resulting in a gradual destruction of the articular cartilage. Matrix components released into body fluids by proteolytic cleavage can be used as biomarkers of ongoing processes. LÄS MER

  5. 4. Cartilage destruction - Release of type IX collagen in joint disease

    Författare :Mikael Danfelter; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cartilage destruction; matrix metalloproteinase 13; ECM; assay; neoepitope; NC4 domain; Type IX collagen; fragment;

    Sammanfattning : Cartilage is of vital importance for the function of joints. It is characterized by a prominent extracellular matrix (ECM) that is produced and maintained by relatively few cells of one type, the chondrocyte. LÄS MER

  7. 5. Collagen VI - Molecular Assembly and Interactions

    Författare :Charlotte Wiberg; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical biology; extracellular matrix; glycosaminoglycan; proteoglycan; collagen; biglycan; decorin; Klinisk biologi;

    Sammanfattning : The extracellular matrix plays an integral role in tissue remodeling and development and it defines the different mechanical properties of a variety of connective tissues. Its complexity in composition and the details in organization has only been partly elucidated. LÄS MER