Sökning: "cartilage destruction"

Visar resultat 1 - 5 av 35 avhandlingar innehållade orden cartilage destruction.

  1. 1. Cartilage destruction - Release of type IX collagen in joint disease

    Författare :Mikael Danfelter; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cartilage destruction; matrix metalloproteinase 13; ECM; assay; neoepitope; NC4 domain; Type IX collagen; fragment;

    Sammanfattning : Cartilage is of vital importance for the function of joints. It is characterized by a prominent extracellular matrix (ECM) that is produced and maintained by relatively few cells of one type, the chondrocyte. LÄS MER

  3. 2. Extracellular Matrix Remodelling-Proteoglycan and collagen turnover in arthritis

    Författare :Anette Bjärdahlen; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Arthritis; collagen; cartilage; myofibroblasts; pannus; proteoglycan; Skeleton; muscle system; rheumatology locomotion; reumatologi; Skelett; muskelsystem;

    Sammanfattning : Rheumatoid arthritis is a chronic, inflammatory and systemic disease characterised by joint destruction and pannus formation. To enlarge the understanding how pannus and granulation tissue are formed two animal models were used; one using cartilage wrapped in cotton and implanted into a rat air pouch (AP) and one where mBSA induced arthritis (AIA) was performed. LÄS MER

  4. 3. The collagen fibrillar network: Sequential degradation of its constituents by tissue metalloproteinases

    Författare :Terrence Heathfield; Enheten för led- och mjukvävnadsforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolism; Metabolism; Biochemistry; collagen; fibromodulin; cartilage; osteoarthritis; Biokemi;

    Sammanfattning : The cartilage matrix is made up of a fibrillar meshwork comprising type II collagen and other associated proteins. One main function of this network is to retain the large aggregating proteoglycan, aggrecan, a vital component in the regulation of fluid flux in cartilage. LÄS MER

  5. 4. Molecular and clinical studies of cartilage and bone macromolecules in arthritis

    Författare :Bengt Månsson; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skeleton; Prognosis; Tissue damage; Bone markers; Cartilage markers; Rheumatoid arthritis; Psoriatic arthritis; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi;

    Sammanfattning : The pathogenesis of inflammatory arthritides include synovial inflammation and joint tissue destruction. Tissue destruction has traditionally been regarded a consequence of inflammation, but recent observations indicate that the processes are not always closely linked and may proceed uncoupled. LÄS MER

  7. 5. Tissue destruction in arthritis : experimental studies

    Författare :Esbjörn Larsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Destruction of joint cartilage and bone is one of the most serious consequences of chronic arthritis. Clinically, the standard assessment of joint destruction is performed by radiography. LÄS MER