Sökning: "N-glycans"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet N-glycans.

  1. 1. Proteoglycan Lectin Domain Interactions in Extracellular Matrix Assembly

    Författare :Anders Olin; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper allmänt ; General biomedical sciences; crystal structure; network formation; collagen IX; N-glycans; PRELP; cross-linking; fibulin-2; lectin; G3; ECM; proteoglycan;

    Sammanfattning : This thesis focuses on the C-terminal G3 region of the large aggregating proteoglycans that are found in complex with hyaluronan in the extracellular matrix. The G3 region contains a C-type lectin domain that binds different extracellular matrix proteins playing an integral role in tissue organization during development and remodeling. LÄS MER

  3. 2. Structural and biochemical insights into biosynthesis and degradation of N-glycans

    Författare :Tom Reichenbach; Christina Divne; David Drew; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; N-glycan; biosynthesis; degradation; glycosyltransferase; glycoside hydrolase; biofuel; enzyme; membrane protein; Bioteknologi; Biotechnology;

    Sammanfattning : Carbohydrates are a primary energy source for all living organisms, but importantly, they also participate in a number of life-sustaining biological processes, e.g. cell signaling and cell-wall synthesis. The first part of the thesis examines glycosyltransferases that play a crucial role in the biosynthesis of N-glycans. LÄS MER

  4. 3. Immune recognition and early virus-cell interactions. Glycobiological aspects on HIV-1 gp120

    Författare :Gregers J. Gram; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human immunodeficiency virus type 1 HIV-1 ; glycoprotein; gp120; glycosylation.;

    Sammanfattning : Human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) are the etiological agents of AIDS in humans. The viral envelope glycoproteins gp120 and gp41 mediate the early virus-cell interaction of HIV with the target cells. LÄS MER

  5. 4. A New Look into Protein C Inhibitor : Posttranslational Modifications and their Functions

    Författare :Wei Sun; Sophia Schedin Weiss; Hakon Leffler; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protein C inhibitor; posttranslational modifications; N-glycan; O-glycan; mass spectrometry; factor Xa; thrombin; prostate specific antigen; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Sammanfattning : The influences of posttranslational modifications on the functions of the versatile serpin protein C inhibitor (PCI) were studied. PCI is a serine protease inhibitor that is expressed in many tissues and secreted to various fluids in human, including blood plasma, seminal plasma, and urine. LÄS MER

  7. 5. Functional differentiation of glycoside hydrolases family 18 in filamentous Ascomycetes

    Författare :Georgios Tzelepis; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Glycoside hydrolases (GH) family 18 includes enzymes such as chitinases and endo-β–Ν-acetylglucosaminidases (ENGases). They are clustered into three distinct phylogenetic groups A, B and C, and further subdivided into several subgroups. LÄS MER