Sökning: "fragment"

Visar resultat 1 - 5 av 536 avhandlingar innehållade ordet fragment.

  1. 1. Fragment-based drug discovery : Novel methods and strategies for identifying and evolving fragment leads

    Författare :Edward A. FitzGerald; Helena Danielson; Hanna-Kirsti Schrøder Leiros; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Drug Discovery; Biophysics; Fragment-based drug discovery; Epigenetics; Biosensors; Surface Plasmon Resonance; Interaction Analysis; Second-Harmonics; Biokemi; Biochemistry;

    Sammanfattning : The need for new drugs became ever more apparent in the year 2020 when the world was faced with a viral pandemic. How drugs are discovered and their relevance to society became part of daily discussions in workplaces and homes throughout the world. Consequently, efficient strategies for preclinical drug discovery are clearly needed. LÄS MER

  3. 2. Introducing weak affinity chromatography to drug discovery with focus on fragment screening

    Författare :Minh-Dao Duong-Thi; Sten Ohlson; Brian Dymock; Linnéuniversitetet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; affinity LC-MS; fragment-based drug discovery; fragment screening; high throughput; mass spectrometry; stereoisomer; enantiomer; thrombin; weak affinity chromatography; WAC; WAC-MS.; Biomedical Sciences; Biomedicinsk vetenskap; Biokemi; Biochemistry;

    Sammanfattning : Fragment-based drug discovery is an emerging process that has gained popularity in recent years. The process starts from small molecules called fragments. One major step in fragment-based drug discovery is fragment screening, which is a strategy to screen libraries of small molecules to find hits. LÄS MER

  4. 3. Concrete Structures Subjected to Fragment Impacts

    Författare :Joosef Leppänen; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; perforation; penetration; strain rate; scabbing; dynamic loading; fragment and projectile impacts; numerical simulations; spalling; concrete; blast wave;

    Sammanfattning : As concrete is commonly used for protective structures, how a blast wave and fragment impacts from an explosion affect the concrete is an important issue. Concrete subjected to explosive loading responds very differently from statically loaded structures. LÄS MER

  5. 4. Towards a New Generation of Anti-HIV Drugs : Interaction Kinetic Analysis of Enzyme Inhibitors Using SPR-biosensors

    Författare :Malin Elinder; U. Helena Danielson; Maurizio Botta; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug discovery; fragment; screening; reverse transcriptase; microbicides; interaction analysis; NNRTIs; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Sammanfattning : As of today, there are 25 drugs approved for the treatment of HIV and AIDS. Nevertheless, HIV continues to infect and kill millions of people every year. Despite intensive research efforts, both a vaccine and a cure remain elusive and the long term efficacy of existing drugs is limited by the development of resistant HIV strains. LÄS MER

  7. 5. Den romantiska postmodernismen. Konstkritiken och det romantiska i 1980- och 1990-talets svenska konst : The Romantic Postmodernism. Art Criticism and the Romanticin Swedish Art in the 1980s and 1990s

    Författare :Kristoffer Arvidsson; Göteborgs universitet; []
    Nyckelord :HUMANIORA; HUMANITIES; post-modernism; romanticism; modernism; art criticism; romantic landscape; romantic irony; fragment; deconstruction; simulation; quotation; collage; painting; Implosion; Ibid.; Ola Billgren; Dick Bengtsson; Max Book; Lars Nittve; Lars O Ericsson; Ingela Lind; Douglas Feuk; PierreBourdieu; Michel Foucault.;

    Sammanfattning : Den romantiska postmodernismen. Through a study of the reception that art critique gave the exhibition project Ibid. LÄS MER