Sökning: "proteinuria"

Visar resultat 31 - 35 av 67 avhandlingar innehållade ordet proteinuria.

  1. 31. Putting the pieces together : elucidation of podocyte biology in the homeostasis of the kidney filtration barrier

    Författare :Patricia M Rodriguez Rivera; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : End-stage renal disease (ESRD) is a devastating condition that can only be treated with chronic dialysis or kidney transplantation. ESRD treatment costs account for up to 10% of healthcare budgets in the Western world. The 5-year survival for patients in dialysis is only about 40%. Glomerular disease processes are the main cause of ESRD. LÄS MER

  3. 32. The expression of the structural proteins dendrin, Plekhh2 and Neph1 in the glomerular filtration barrier

    Författare :Jenny Hulkko; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: The podocytes are injured in many acquired glomerular diseases. This may present as proteinuria or morphological changes such as foot process effacement (FPE) or loss of podocytes in the urine. The exact mechanisms are still mainly unknown. LÄS MER

  4. 33. Immunoglobulin A nephropathy and disease complications : register-based studies

    Författare :Simon Jarrick; Jonas Ludvigsson; Sigrid Lundberg; Adina Symreng; Colin C. Geddes; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunoglobulin A nephropathy; nephrology; validation studies; register studies; cohort studies; mortality; ischemic heart disease; pregnancy; preterm birth;

    Sammanfattning : Immunoglobulin A nephropathy (IgAN) is the commonest primary glomerular disease worldwide. A kidney biopsy is required for the diagnosis. IgA immune-complex depositions sets off a cascade leading to renal scarring, proteinuria and hypertension. LÄS MER

  5. 34. Kidney Hyaluronan : Regulatory Aspects During Different States of Body Hydration, Nephrogenesis & Diabetes

    Författare :Louise Rügheimer; Peter Hansell; Cecilia Johnsson; Örjan Källskog; Mats Rundgren; Uppsala universitet; []
    Nyckelord :Physiology; hyaluronan; kidney; dehydration; hydration; diabetes; nephrogenesis; renomedullary interstitial cells; CD44; hyaluronan synthase; hyaluronidase; vasopressin; nitric oxide; prostaglandins; glucocorticoids; angiotensin II; diuresis; lymph vessel; podoplanin; Fysiologi;

    Sammanfattning : The kidney regulates the excretion of water and electrolytes, which maintains homeostasis and enables control of arterial blood pressure. Hyaluronan, a large negatively charged interstitial glucosaminoglycan, is heterogeneously distributed within the kidney, primarily found in the medulla. LÄS MER

  7. 35. Effects of PDGF-B gene inactivation in endothelial cell

    Författare :Mattias Bjarnegård; Göteborgs universitet; []
    Nyckelord :gene targeting; Cre loxP; PDGF; pericyte; mouse; microangiopathy;

    Sammanfattning : Platelet-derived growth factor-B (PDGF-B) is expressed by endothelial cells, neurons, macrophages and platelets. The relative importance of these cellular PDGF-B sources in vivo has been addressed by the creation of a conditional PDGF-B allele, which in the presence of a specific recombinase can be silenced in different tissues. LÄS MER