Sökning: "nephrogenesis"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet nephrogenesis.

  1. 1. Kidney Hyaluronan : Regulatory Aspects During Different States of Body Hydration, Nephrogenesis & Diabetes

    Författare :Louise Rügheimer; Peter Hansell; Cecilia Johnsson; Örjan Källskog; Mats Rundgren; Uppsala universitet; []
    Nyckelord :Physiology; hyaluronan; kidney; dehydration; hydration; diabetes; nephrogenesis; renomedullary interstitial cells; CD44; hyaluronan synthase; hyaluronidase; vasopressin; nitric oxide; prostaglandins; glucocorticoids; angiotensin II; diuresis; lymph vessel; podoplanin; Fysiologi;

    Sammanfattning : The kidney regulates the excretion of water and electrolytes, which maintains homeostasis and enables control of arterial blood pressure. Hyaluronan, a large negatively charged interstitial glucosaminoglycan, is heterogeneously distributed within the kidney, primarily found in the medulla. LÄS MER

  3. 2. The renin-angiotensin system in renal tubulogenesis. Experimental studies in the rat

    Författare :Daina Lasaitiene; Göteborgs universitet; []
    Nyckelord :angiotensin II; extracellular matrix; inflammation; mitochondrial biogenesis; renal development; renin-angiotensin system; thick ascending limb of Henle; tubulogenesis;

    Sammanfattning : The kidney and the renin-angiotensin system (RAS) are vital regulators of blood pressure and salt-water balance. In order to appropriately regulate circulatory homeostasis, the kidney must undergo normal development, in which the RAS plays a crucial role. LÄS MER

  4. 3. The developing rat kidney : the dopamine system and related serine/threonine kinases and phosphatases

    Författare :Johan Svennilson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :apoptosis; confocal immunofluorescence; DARPP-32; dopamine; foetal renal development; hypertension; in situ hybridization; metanephric culture; mouse; nephron number; PKC; PP1 PP2A; protein phosphorylation; rat;

    Sammanfattning : The kidney originates from the fusion and conversion of two tissues: the metanephric mesenchyme and the ureter epithelium, an evagination from the Wolffian duct. Although a number of candidate molecules have been shown to be of importance for the differentiation of the embryonic kidney, many of the signalling pathway leading to this development are still obscure. LÄS MER

  5. 4. Na,K-ATPase as signaling transducer

    Författare :Juan Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : It is now generally agreed that Na,K-ATPase (NKA), in addition to its role in the maintenance of Na+ and K+ gradients across the cell membrane, is a signal transducer. Our group has identified a novel signaling pathway where NKA interact with IP3R to form a signaling microdomain. LÄS MER

  7. 5. Regulation of Renal Hyaluronan in Water Handling : Studies in vivo and in vitro

    Författare :Sara Stridh; Peter Hansell; Mats Rundgren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; water balance; fluid handling; diabetes; nephropathy; ACE fetopathy; reabsorption; hyaluronic acid; glycosaminoglycan; GAG; extracellular matrix; mTOR; rapamycin; streptozotocin;

    Sammanfattning : Hyaluronan (HA) is a negatively charged extracellular matrix (ECM) component with water-attracting properties. It is the dominating ECM component in the renal medullary interstitium, where the amount changes in relation to hydration status: it increases during hydration and decreases during dehydration. LÄS MER