Sökning: "protein kinase C"

Visar resultat 41 - 45 av 306 avhandlingar innehållade orden protein kinase C.

1. 41. Lipid Signalling Dynamics in Insulin-secreting β-cells

   Författare :Anne Wuttke; Anders Tengholm; Erik Gylfe; Louis Philipson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ATP; β-cell; diacylglycerol; insulin secretion; oscillations; PtdIns 4 P; PtdIns 4; 5 P2; protein kinase C; P2Y receptor; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Certain membrane lipids are involved in intracellular signalling processes, among them phosphoinositides and diacylglycerol (DAG). They mediate a variety of functions, including the effects of nutrients and neurohormonal stimuli on insulin secretion from pancreatic β-cells. LÄS MER

3. 42. Protein Kinase C as an Apoptosis Regulator and a Potential Prognostic Factor in Breast Cancer

   Författare :Gry Kalstad Lönne; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Several protein kinase C (PKC) isoforms have been suggested as potential targets for breast cancer therapy. To explore the role for PKC isoforms in processes that facilitates malignant progression and the utility of PKC isoforms as biomarkers in breast cancer, we designed a study where we evaluated the expression of PKCα, δ, and ε in primary breast cancers as well as in breast cancer cell lines. LÄS MER

4. 43. Effects of Antioxidant and Lipid Lowering Treatment on Risk Factors for Cardiovascular Disease : With special reference to Mixed Tocopherols and Stable Fish Oil

   Författare :Meilin Liu; Afaf Kamal-Eldin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Cardiovascular disease; Antioxidants; Tocopherols; Endothelial constitutive nitric oxide synthase; Superoxide dismutase; Protein kinase C; Fish oils; Fatty acids; Simvastatin; Lipoprotein; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; rättsmedicin; Forensic Medicine;

   Sammanfattning : Vitamin E in food, polyunsaturated fatty acids (PUFAs) and lipid lowering treatment with statins have been found to decrease the risk for cardiovascular disease (CVD) and cardiac death. However, clinical trials revealed no beneficial effect of intake of alpha-tocopherol alone. LÄS MER

5. 44. Glucose and insulin modulate phagocytosis and production of reactive oxygen metabolites in human neutrophil granulocytes

   Författare :Daniel Saiepour; Per-Arne Oldenborg; Janove Sehlin; Olle Stendahl; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophil granulocytes; glucose; insulin; protein kinase C; diacylglycerol; phagocytosis; respiratory burst; diabetes; Histology; Histologi;

   Sammanfattning : Neutrophil granulocytes play an important role in the host defence against invading microorganisms and constitute the frontline of defence within the innate immune system and are among the first cells to arrive at the site of inflammation. Effective phagocytosis and killing of invading pathogens by neutrophils is of significant importance for successful resistance to infectious diseases. LÄS MER

7. 45. Pancreatitis-Associated Pulmonary Injury

   Författare :Xia Zhao; Lund Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; orthopaedics; Surgery; inflammatory mediators; protein kinase C; leukocytes; acute lung injury; abdominal sepsis; acute pancreatitis; traumatology; Kirurgi; ortopedi; traumatologi;

   Sammanfattning : In acute pancreatitis (AP), lung injury is an early occuring and important part of the multiple organ dysfunction syndrome. The mechanisms underlying the development of lung injury though still largely remains unclear. LÄS MER