Sökning: "pre-clinical trial"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden pre-clinical trial.

  1. 1. Development and application of a patient-derived xenograft platform to test anticancer agents

    Författare :Berglind Einarsdottir; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; malignant melanoma; patient-derived xenografts; MTH1; pre-clinical trial; Karonudib;

    Sammanfattning : Malignant melanoma is the most aggressive form of skin cancer and incidence rates are on the rise. Despite recent improvements in treatment options, the disease still remains lethal. Which calls for expedited solutions. LÄS MER

  3. 2. eVIS – A digital support for physical activity in patients with chronic pain

    Författare :Veronica Sjöberg; Linda Vixner; Björn Äng; Maria Hagströmer; Mathilda Björk; Pernilla Åsenlöf; Högskolan Dalarna; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic pain; Criterion validity; Content validity; Complex intervention development; Device-based measurement; Feasibility; Physical activity;

    Sammanfattning : Background: Chronic pain is a significant contemporary health challenge, exerting enormous impact on both individuals and societies. Although physical activity is the primary treatment, many patients struggle with incorporating it into their lives. LÄS MER

  4. 3. Pharmacometric Models to Improve the Treatment and Development of Drugs against Tuberculosis

    Författare :Robin J. Svensson; Ulrika S H Simonsson; Mats O Karlsson; Andreas Krause; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics; Pharmacodynamics; Biomarkers; Rifampicin; Clofazimine; Therapeutic drug monitoring; Time-to-event; Time-to-positivity; Molecular bacterial load assay; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : With 10 million new infections yearly, tuberculosis has a major impact on the human well-being of the world. Most patients have infections susceptible to a first-line treatment with a treatment success rate of 80%, a number that can potentially be improved by optimising the first-line treatment. LÄS MER

  5. 4. Virtual patients for education, assessment and research : a web-based approach

    Författare :Nabil Zary; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Virtual patients; computer simulation; patient simulation; computer-based learning; computer-assisted instruction; computer-managed instruction; problem solving; clinical reasoning; clinical knowledge; computer assisted cases; interactive case-based learning.;

    Sammanfattning : Virtual simulations of patient encounters have been an increasingly important complement in the development of healthcare competence. Virtual patients (VPs) are interactive computer programs that simulate real-life clinical scenarios, provide an effective way for healthcare professionals and students to not only learn about a wide range of clinical topics, but also to practice in a virtual and therefore safe environment. LÄS MER

  7. 5. Model-based Approaches to Diffuse Optical Imaging and Dosimetry

    Författare :Johan Axelsson; Atomfysik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; photodynamic therapy; diffuse light propagation; fluorescence; imaging; dosimetry; inverse problem;

    Sammanfattning : The work within this thesis investigates Photodynamic therapy and Fluorescence imaging for therapeutics and visualization of deeply embedded lesions. Photodynamic therapy (PDT) is a cancer treatment modality that can eradicate tumors when light, a photosensible drug and oxygen are present. LÄS MER