Sökning: "posttranscriptional"

Visar resultat 11 - 15 av 31 avhandlingar innehållade ordet posttranscriptional.

  1. 11. Functional studies of microRNAs in development and cancer

    Författare :Jakob Lovén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : MicroRNAs (miRNAs) COMPRISE a large family of small (~23 nucleotide in length), endogenous RNAs that regulate gene expression at the posttranscriptional level. Functional studies have indicated that miRNAs participate in the regulation of nearly all cellular processes investigated so far, including differentiation, apoptosis, and proliferation. LÄS MER

  3. 12. Genetics of Tetrapyrrole Synthesis in Gram-Positive Bacteria

    Författare :Per Johansson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microbiology; siroheme; tetrapyrrole synthesis; Bacillus subtilis; Bacillaceae; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : The organization and regulation of genes for tetrapyrrole synthesis were studied in low G+C Gram-positive bacteria. Clusters of genes encoding enzymes for tetrapyrrole biosynthesis were cloned from Bacillus sphaericus, Bacillus stearothermophilus, Brevibacillus brevis and Paenibacillus macerans. LÄS MER

  4. 13. Structural and Functional Studies of the Wilms' Tumour 1 Protein (WT1) in Interaction with Nucleic acids

    Författare :Raymond Yengo Kimbung; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; WT1; Zinc finger; Structure; Transcription factor;

    Sammanfattning : The WT1 protein, a product of the Wilms’ tumour 1 gene (WT1) is a zinc finger transcription factor implicated in a number of cellular processes particularly involved in the development of the urogenital system. Mutations in this gene have been implicated in abnormal development of the urogenital system resulting in syndromes such as the Denys-Drash, WAGR and Frasier and in the childhood kidney malignancy, Wilms’ tumour. LÄS MER

  5. 14. The odyssey of MYC transcript from the nucleus to the cytoplasm : the molecular mechanism of the gene gating in human cancer cells

    Författare :Mirco Martino; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pathological expression of the MYC oncogene is a common denominator in a wide range of cancers and is linked with abnormal cell proliferation. To achieve this status, the MYC gene benefits from being embedded in a region rich in enhancers and super-enhancers that are often absent in the normal cell counterparts. LÄS MER

  7. 15. Untangling the contribution of untranslated regions to mRNA translation in health and disease

    Författare :Johannes Ristau; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protein homeostasis is essential for living organisms and a consequence of steps of the gene expression pathway such as transcription, mRNA translation as well as the degradation of mRNA and proteins. These major cellular events demand tight control, high maintenance, and require a large proportion of cellular resources. LÄS MER