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Visar resultat 1 - 5 av 46 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Unraveling the immune response in sepsis and meningitis. Diagnostic and therapeutic approaches

   Författare :Jane Fisher; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; meningtis; sepsis; neutrophil extracellular traps NETs ; glymphatic system; DNase; pneumococci;

   Sammanfattning : Severe infections continue to constitute a large burden, with high mortality and risk of sequelae. Sepsis is a dysregulated host response to an infection that causes life threatening organ damage. Meningitis is a severe infection of the brain that often leads to sepsis and death or lasting neurological damage. LÄS MER

3. 2. Infectious and bleeding complications in patients with hematological malignancies : Studies on diagnosis and prevention

   Författare :Tobias Svensson; Honar Cherif; Martin Höglund; Jan Sjölin; Christine Wennerås; Uppsala universitet; []
   Nyckelord :Chronic lymphocytic leukemia; Immunodeficiency; Hypogammaglobulinemia; IgG subclass; Pneumococci; Pneumococcal vaccine; Polysaccharide vaccine; Protein-conjugate vaccine; Aspergillosis; Bronchoalveolar lavage; Invasive fungal disease; Pneumocystis jirovecii pneumonia; Myelodysplastic syndrome; Azacitidine; Eltrombopag; Thrombocytopenia; Thrombopoietin receptor; Oncology; Onkologi;

   Sammanfattning : The overall aim of this thesis is to improve knowledge about the prevention of infectious and bleeding complications in patients with hematological malignancies, primarily in those with chronic lymphocytic leukemia (CLL) and myelodysplatic syndrome (MDS).Hypogammaglobulinemia, impaired production of immunoglobulins (Ig), is an established risk factor for infection, but the impact of IgG pure subclass deficiency (IgG subclass deficiency with adequate production of IgG, IgA, and IgM) has been debated. LÄS MER

4. 3. Resistant pneumococci and use of antibiotics

   Författare :Eva Melander; Malmö Klinisk mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bakteriologi; Mikrobiologi; mycology; virology; streptococcus pneumoniae; Antibiotics; drug resistance; bacteriology; Microbiology; virologi; mykologi;

   Sammanfattning : Pneumococcal resistance to antibiotics has become a worldwide problem. The rapid increase in frequency seems to be caused by intercontinental spread of a few resistant clones. Resistance to antibiotics in pneumococci has reduced the therapeutic arsenal for common respiratory tract infections as well as for invasive infections. LÄS MER

5. 4. Penicillin-resistant pneumococci in Sweden : epidemiology and public health response

   Författare :Liselotte Högberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Streptococcus pneumoniae; penicillin resistance; epidemiology; surveillance; validity; public health interventions; day care centres; antibiotic use.;

   Sammanfattning : Since 1996, all identified cases of pneumococci with a MIC for penicillin G > 0.5 mg/L (penicillin resistant pneumococci: PRP) have been registered according to the Swedish Communicable Disease Act. LÄS MER

7. 5. Role of HAMLET and metabolism in treatment and pathogenesis of pneumococci

   Författare :Goutham Vansarla; Malmö Experimentell infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococcus pneumoniae; Antibiotic resistance; Alpha-lactalbumin; HAMLET; Biofilms; Bacterial metabolism; Immunomodulatory effects.;

   Sammanfattning : Antimicrobial resistance (AMR) is one of the principle public health problems in the 21st century, threatening the available treatment strategies for bacterial infections. Here, we present a human protein-lipid complex, HAMLET (human alpha-lactalbumin made lethal to tumor cells) purified from human milk as a potential therapeutic agent which has both tumoricidal and bactericidal activity. LÄS MER