Sökning: "Aspergillosis"
Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet Aspergillosis.
1. Infectious and bleeding complications in patients with hematological malignancies : Studies on diagnosis and prevention
Sammanfattning : The overall aim of this thesis is to improve knowledge about the prevention of infectious and bleeding complications in patients with hematological malignancies, primarily in those with chronic lymphocytic leukemia (CLL) and myelodysplatic syndrome (MDS).Hypogammaglobulinemia, impaired production of immunoglobulins (Ig), is an established risk factor for infection, but the impact of IgG pure subclass deficiency (IgG subclass deficiency with adequate production of IgG, IgA, and IgM) has been debated. LÄS MER
2. Analysis of Secondary Metabolites from Aspergillus fumigatus and Penicillium nalgiovense : Antimicrobial Compounds from Filamentous Fungi Isolated from Extreme Environments
Sammanfattning : This thesis describes the cultivation and extraction of filamentous fungi isolated from extreme environments in the search for new antibiotic compounds. Filamentous fungi are a rich source of medicines including antibiotics, and it is believed that many currently unknown fungal species and bioactive fungal metabolites remain to be discovered. LÄS MER
3. Invasive fungal disease in immunocompromised hosts with focus on diagnostics
Sammanfattning : Invasive fungal diseases (IFDs) are severe conditions affecting immunocompromised patients. The primary aim of this thesis was to explore different methods for diagnosis of IFD in different groups of immunocompromised patients. Papers I and II included patients with hematologic disorders. LÄS MER
4. Catalytic and Structural Properties of Heme-containing Fatty Acid Dioxygenases : Similarities of Fungal Dioxygenases and Cyclooxygenases
Sammanfattning : 7,8-Linoleate diol synthase (7,8-LDS) of the take-all pathogen of wheat, Gaeumannomyces graminis, converts linoleic acid to 8R-hydroperoxyoctadecadienoic acid (8-HPODE) by 8-dioxygenase activity (8-DOX), and further isomerizes the hydroperoxide to 7S,8S-dihydroxyoctadecadienoic acid (7,8-DiHODE) by hydroperoxide isomerase activity. Sequence alignment showed homology to prostaglandin H synthase (PGHS), and both enzymes share structural and catalytic properties. LÄS MER
5. Studies on laboratory diagnosis of fungal infection and antifungal susceptibility
Sammanfattning : Invasive fungal infections (IFI) are serious complications in immunocompromised hosts. Neutropenic patients with haematological malignancies or after transplantation are at risk of developing deep Candida or Aspergillus infections. LÄS MER